INFRAFRONTIER Seminar: Recent Advances in Human Disease Modeling
Leena Palotie Hall, Aapistie 5A, 90220 Oulu or via Zoom
INFRAFRONTIER is a pan-European research infrastructure that integrates repositories of the European Mouse Mutant Archive (EMMA) network, the world’s 3rd largest mouse strain repository, and European Mouse Clinics, centers of excellence for systemic phenotyping of mouse models. The University of Oulu represents Finland in INFRAFRONTIER and Biocenter Oulu Transgenic and Tissue Phenotyping Core serves as the Finnish EMMA node.
This event gathers European INFRAFRONTIER partners together to present their recent achievements in biomedicine and technological advances in modeling human diseases. The event aims to disseminate the knowledge gained from INFRAFRONTIER activities to the biomedical community ensuring effective access to the most recent disease models and analyzing methods in the field.
Registration by Wed 25th May via this registration form.
09:00 - 09:05 Opening words, Reetta Hinttala, Associate Professor (tenure track), PEDEGO, University of Oulu
09:05 - 09:30 Humanized mice model of Sars-Cov-2 infection as a translational approach to evaluate the efficacy of therapeutic candidates and decipher the mechanism of COVID19 pathology, Ana Zarubica, PhD, Scientific Coordinator of COVID19/Respiratory Infection Task Force CIPHE, France
09:30 - 09:55 Dissection the complexity of host Susceptibility to type 2 diabetes development, Prof. Fuad A. Iraqi, Genetics of Complex Traits Research, Tel Aviv University, Israel
09:55 - 10:20 TANC2: an NDD risk gene with medical comorbidities, Sabine Hölter-Koch, PhD, Behavioral Neuroscience Team, Helmholtz Zentrum München, Germany
10:20 - 10:50 COFFEE BREAK
10:50 - 11:15 A pipeline for the study of neuronal interaction with tumor cells in mouse models of glioblastoma based on fluorescent biosensors and intravital multiphoton microscopy, Prof. Fabio Mammano, PhD, M.Phil., University of Padova, Italy (remote)
11:15 - 11:35 AI supported data analysis in phenotyping, Elida Schneltzer, Institute of Experimental Genetics, Helmholtz Zentrum München, Germany
11:35 - 12:00 A new perspective from rat models for a better understanding of cognitive dysfunction in Down Syndrome, Yann Herault, PhD, Institut Clinique de la Souris, France
Genetically modified mouse models are irreplaceable for basic and biomedical research. The mouse shows great similarities in development, physiology, and biochemistry to humans, which makes it a key model for research into human disease. The use of animal models also facilitates the translation of knowledge from basic research into therapeutic approaches, personalized medicine, and disease prevention strategies.
The INFRAFRONTIER research infrastructure provides access to first-class research tools and data for biomedical research and thereby contributes to improving our understanding of gene function in human health and disease using the mouse as a model.