Novel ultrafast NMR method for investigating molecular exchange

The exchange of molecules between different physical or chemical environments due to diffusion or chemical transformations has a crucial role in a plethora of fundamental processes such as breathing, protein folding, chemical reactions and catalysis.

The NMR Research Unit at the University of Oulu developed an NMR method to speed up to 10000-fold detection of molecular exchange. The method is exploited in the climate change research to understand the composition of atmospheric aerosols in collaboration with the Nano and Molecular Systems (NANOMO) Research Unit at the University of Oulu.

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most versatile spectroscopic methods. NMR spectra are kind of fingerprints of molecules. The method provides also detailed information on the motion and positions of molecules. The most well-known application of NMR phenomenon is the Magnetic Resonance Imaging (MRI) method used in hospitals.

Molecular exchange phenomena can be studied by so-called Diffusion EXchange SpectroscopY (DEXSY). The method is based on the fact that, when the environment of a molecule changes, its diffusion coefficient, which represents the amount of thermal motion, changes as well. However, the conventional DEXSY method is slow, as each point of multidimensional data has to be collected in separate measurements. Based on spatial encoding of multidimensional data, the NMR Research Unit developed an ultrafast DEXSY experiment, by which the data could be collected in a single scan.

The method was exploited in the investigation of surfactants present in atmospheric aerosols. The study revealed that the surfactants form nanovesicles, which encapsulate water molecules. The method was used to determine how quickly water molecules moved from inside vesicles to outside of them. Structures formed by surfactants can have a significant impact on the surface tension of cloud droplets and, therefore, on climate models.

The study was published in the prestigious journal Nature Communication. The study is related to the projects ”Ultrafast Laplace NMR” (2.6 M€, Principal Investigator: Prof. Ville-Veikko Telkki) and SURFACE (1.5 M€, Principal Investigator: Associate Prof. Nønne Prisle) supported by European Research Council (ERC).

Otto Mankinen, Vladimir V. Zhivonitko, Anne Selent, Sarah Mailhiot, Sanna Komulainen, Nønne L. Prisle, Susanna Ahola and Ville-Veikko Telkki: Ultrafast Diffusion Exchange Nuclear Magnetic Resonance, Nature Communications, 11, 3251 (2020).

Last updated: 17.12.2021