COCOA enzyme engineering


We want to change the substrate specificity of rat mitochondrial 2E-enoyl-CoA hydratase (ECH) such that this enzyme can be used for the sustainable synthesis of building blocks for making valuable biopharmaceuticals and fine chemicals
for the cocoa website
ECH is a hexamer. Each active site has two catalytic glutamates and an oxyanion hole

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This is a joint enzyme engineering project with the research groups of Prof. Pihko and Prof. Groenhof at the University of Jyväskylä