COCOA enzyme engineering

COCOA

We want to change the substrate specificity of rat mitochondrial 2E-enoyl-CoA hydratase (ECH) such that this enzyme can be used for the sustainable synthesis of building blocks for making valuable biopharmaceuticals and fine chemicals
for the cocoa website
ECH is a hexamer. Each active site has two catalytic glutamates and an oxyanion hole

Project information

Project duration

-

Project coordinator

Other university or unit

Contact information

Project leader

  • Emeritus Professor
    Rik Wierenga

Project description

This is a joint enzyme engineering project with the research groups of Prof. Pihko and Prof. Groenhof at the University of Jyväskylä