Breast Cancer Genetics Research Group

Breast cancer is the most common cancer among women. It is influenced by hereditary risk factors, but the known predisposing alleles explain less than half of its hereditary component, leaving causal factor for the majority of breast cancer families unknown. Our aim is to identify and characterize additional predisposing genetic changes using various genomic approaches in Northern Finnish breast cancer cohorts. The obtained results refine the clinical risk assessment, increase the understanding of the etiology of breast cancer and promote the development of more targeted therapies.

Research group information

Contact information

Research group leader

Research group description

The focus of our Breast Cancer Genetics team is on resolving the molecular genetics and biology behind the inherited breast cancer predisposition. For this we use breast cancer case cohorts collected from Northern Finnish population with homogenous genetic background and implement several high-throughput genomic methods for their comprehensive genetic analysis. The effects of the breast cancer predisposing variants are investigated with functional genomics, biochemical and tumor modelling approaches, which can provide important insights into the tumorigenesis mechanisms and may lead to implementation of more effective diagnostic and prognostic tools, as well as targeted treatment.

Our Team

Where are we headed

We anticipate that this project combining the expertise in molecular and clinical genetics, biochemical investigations, and tumor modelling together with the dedicated collaborators will refine the clinical risk assessment of high-risk individuals, increase the understanding of the cellular mechanisms behind breast cancer development and ultimately promote the development of more targeted cancer therapies.

Our main collaborators

  • Clinicians and clinical researchers at Oulu University Hospital
  • Clinical laboratory geneticists at Nordlab Oulu
  • Breast cancer Association Consortium
  • PALB2 interest group