The mechanisms of dysfunctional immunity

Research group information

Contact information

Research group leader

  • Professor
    Timo Hautala

Research group description

The knowledge on the genetics and biology behind the infection susceptibility and immunological disorders is growing fast. Currently, hundreds of mutations are known to be involved in the dysfunctions of immune system. We have identified multiple novel genetic variants in the Northern Finnish families that potentially underlies their altered immunological phenotype and disease. The mutations we have identified predisposes the carrier to infections, autoimmunity or for example, to aberrant inflammatory response.

Our goal is to explore the biology and molecular mechanisms behind the function of the novel genetic variants using various methods of molecular biology, immunological phenotyping, and clinical studies. We are are interested in examining for example the immune cell behavior and regulation of inflammatory responses.

Our team

  • Antti Nissinen, MSc, PhD
  • Pirjo Åström, MSc, PhD
  • Nora Pernaa, MSc
  • Wenny Santaniemi, MSc
  • Rita Baker, BSc
  • Ella-Nora Tallgren, undergraduate student (medicine)
  • Anna Mikola, undergraduate student (medicine)
  • Anni Vakkuri, undergraduate student (medicine)

Our main collaborators

  • Prof. Mikko Seppänen, University of Helsinki, Finland
  • Adj. prof. Markku Varjosalo, University of Helsinki, Finland
  • Prof. Kari Eklund, University of Helsinki, Finland
  • Prof. Jean-Laurent Casanova, University of Rockefeller, NY, USA,
  • Prof. Janna Saarela, University of Oslo, Norway
  • Adj. prof. Outi Kuismin, Oulu University Hospital, Finland
  • Prof. Kathleen E. Sullivan, Childrens’ Hospital of Philadelphia Research Institute, USA
  • Prof. Petri Lehenkari, University of Oulu, Finland
  • Prof. Thomas Kietzmann, University of Oulu, Finland

How to contact us