Investigation of treatments to enhance cerebrospinal fluid flow in the brain: blood pressure lowering and whole-body vibration

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Leena Palotie -hall, Aapistie 5A

Topic of the dissertation

Investigation of treatments to enhance cerebrospinal fluid flow in the brain: blood pressure lowering and whole-body vibration

Doctoral candidate

Master of Science Jari Jukkola

Faculty and unit

University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, ECM and hypoxia

Subject of study

Animal physiology, neuroscience

Opponent

Assistant Professor Erik. N.T.P. Bakker, University of Amsterdam

Custos

Professor Lauri Eklund, Oulun yliopisto

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Enhancing cerebrospinal fluid flow by blood pressure lowering and whole-body vibration

One of the most important functions of the cerebrospinal fluid is the facilitation of brain clearance by removing the metabolites it produces. This function can be significantly weakened, for example by hypertension. In my PhD thesis, I show how acute blood pressure lowering and whole-body vibration enhance the clearance of circulating brain metabolites via the cervical lymphatic pathway in mice. The clinical impact of my findings might be great for example in preventing neurodegenerative diseases such as Alzheimer's.
Last updated: 17.11.2022