Investigation of treatments to enhance cerebrospinal fluid flow in the brain: blood pressure lowering and whole-body vibration
Thesis event information
Date and time of the thesis defence
Place of the thesis defence
Leena Palotie -hall, Aapistie 5A
Topic of the dissertation
Investigation of treatments to enhance cerebrospinal fluid flow in the brain: blood pressure lowering and whole-body vibration
Doctoral candidate
Master of Science Jari Jukkola
Faculty and unit
University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, ECM and hypoxia
Subject of study
Animal physiology, neuroscience
Opponent
Assistant Professor Erik. N.T.P. Bakker, University of Amsterdam
Custos
Professor Lauri Eklund, Oulun yliopisto
Enhancing cerebrospinal fluid flow by blood pressure lowering and whole-body vibration
One of the most important functions of the cerebrospinal fluid is the facilitation of brain clearance by removing the metabolites it produces. This function can be significantly weakened, for example by hypertension. In my PhD thesis, I show how acute blood pressure lowering and whole-body vibration enhance the clearance of circulating brain metabolites via the cervical lymphatic pathway in mice. The clinical impact of my findings might be great for example in preventing neurodegenerative diseases such as Alzheimer's.
Last updated: 23.1.2024