Photo: Cultured human mesenchymal stem cells labelled with Mitotracker and quantum dots, by Pietilä, Lehenkari & Uemura
Bone and Stem Cell Biology Research Group
Research unit: Cancer and Translational Medicine
Professor Petri Lehenkari (MD, PhD)
What do we do
Stem cells are the body's main facilitator in the development and the growth and regeneration and maintenance of adult tissues. Stem cells are deeply involved in the inflammatory process and enable the regulation of any tissue repair after injury.
Our stem cell research group examines the mesenchymal stem cells isolated from various tissues of adult and cord blood. We investigate cell activity under normal circumstances, rheumatoid arthritis, organ repair and cancer. Stem cells are collected in Oulu University Hospital patients who have given their consent to the study. We do not do research on embryonic stem cells.
Currently we are also focusing on adverse reactions on metal-on-metal orthopedic implants. Metal- on metal implant catastrophe and consequent clinical studies have revealed that adverse tissue reactions occur more often than earlier anticipated and the incidence of clinical case reports of any kind of metal reactions is in exponential rise at the moment. Hence, all understanding of the true nature of metal and foreign body reaction in general are essential for further development of the implants. Our collection of tissue material from real patients combined with live cell cultures provides a unique translational approach to this phenomenon experimentally.
Post doc researchers
- Huhtakangas Johanna
- Turunen Sanna
- (Tarja Tanner)
- (Maarit Valkealahti)
- Aho Olli-Matti
- Avila Inari
- Heikkinen Tero
- Huovinen Jere
- Nousiainen Tomi
- Vuoti Ella
Where are we headed
The on-going research in our group focuses on stem cell biology in rheumatic diseases and adverse effects in orthopedic implants.
Our main collaborators
How to find us
Please see our videos of human mesenchymal stem cells 100 h in culture:
Last updated: 9.7.2019