Porvari Katja

Molecular changes connected to cold exposure and hypothermia


Group leader

Docent Katja Porvari, PhD


What do we do

Exposure to excessive cold is dangerous for organs, but controlled coldness can also be exploited in medicine. In this study we are looking for cold-induced molecular changes that are affecting organs. We are also investigating how the cold-induced stress differs from other stress-reactions, and how tissue-specific reactions diverge. Principal aim is to identify and analyze functional changes of genes and mechanisms behind them. We are especially interested in molecular changes occurring in the heart tissue, and our results have connections to heart diseases and deaths. Identification of molecular markers specific to cold can also be utilized in forensic death cause investigations.


Our team

Post doc researchers

  • Kaija Helena, PhD
  • Pakanen Lasse, MD, PhD


Where are we headed

Understanding of molecular events connected to cold exposure and hypothermia could generate new possibilities to prevent their injurious effects or promote their valuable effects in cells and tissues. Controlled cold exposure could be more efficiently used e.g. to protection of tissues against oxygen deficiency during surgery or to inhibit inflammation and chronic pain.


Our main collaborators 

Forensic Medicine, National Institute for Health and Welfare, Oulu, Finland


How to find us


Last updated: 9.7.2019