Jukka Hakkola

Jukka Hakkola

MD, PhD

Professor of Pharmacology
Pharmacology and Toxicology

81 peer reviewed publications in international journals. The publications have been cited 4378 times, of which the most cited publication accounts for 390 citations. The author has a h-index of 39.00. (Scopus (Sep 10 2021))

Biography

Jukka Hakkola is a Professor of Pharmacology since 2009 and the Head of the Research Unit of Biomedicine since 2014. Hakkola has over 25 years of experience in the pharmacology and toxicology and hepatic cell and molecular biology. His research interests have focused on nuclear receptors and cytochrome P450 enzymes, during the recent years especially on hepatic energy metabolism with the aim to understand how hepatocytes sense nutritional and environmental exposure and adjust metabolic functions in response. Currently, his main research target is a xenobiotic-sensing nuclear receptor PXR. His team investigates the role PXR in regulation of glucose and lipid metabolism and in development of metabolic diseases such diabetes, non-alcoholic liver disease and the metabolic syndrome. He has also publications and ongoing work on the energy sensing factors, sirtuins and the coactivator PGC-1α, and on vitamin D metabolism. He is also a partner in an EU project, EDCMET, aiming to develop novel methods and models to assess the metabolic effects of endocrine disruptors and to identify relevant molecular initiating events linked to the adverse outcomes.

Research interests

  • Metabolic pharmacology
  • Xenobiotic-sensing nuclear receptors, especially PXR
  • Diabetes and metabolic syndrome
  • Fatty liver disease (NAFLD)
  • Hepatic molecular biology
  • Endocrine disrupting chemicals
  • Cytochrome P450 enzymes

Major research funding

Academy of Finland, 2015-2019 and 2019-2023

EU Horizon 2020, ECDMET; partner and work pakage leader, 2019-2023

Databases

Social media

Professional and community activities

  • President of the Finnish Pharmacological Society 2011-2013

Research visits

  • Postdoctoral research fellow, Karoliska Institutet, Stockholm, Sweden, 1998-1999

  • Visiting professor, the University of Queensland, Australia, 2011