Khaled Abass

Adjunct Professor, European Registered Toxicologist

Arctic Health, Faculty of Medicine, University of Oulu, Finland

Khaled Abass

PhD

Environmental Toxicology and Human Helath Risk Assessment

36 peer reviewed publications in international journals. The publications have been cited 578 times. The author has a h-index of 13.00. (Google Scholar)

Biography

A Senior Toxicologist at Arctic Health, Faculty of Medicine, University of Oulu, Finland. In 2010, he received his PhD from Faculty of Medicine, University of Oulu, Finland, specializing in environmental toxicology and human health risk assessment. In 2011, he has accorded the title of a Certified European Registered Toxicologist ‘ERT’ by the Federation of European Toxicologists & European Societies of Toxicology EUROTOX. In 2014, he has granted Adjunct Professor in Environmental Toxicology from the University of Helsinki, Finland.

Research interests

  • Environmental Toxicology
  • Human Health Risk Assessment

Projects

  • EU Horizon2020 Project825762 -Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways
  • EU Horizon2020 Project773421- Nunataryuk (Permafrost thaw and the changing Arctic coast) WP5 Health and Pollution
  • One Health project: One Arctic – One Health: Animal and human health in the changing climate- Arctic Council’s Sustainable Development Working Group.
  • Arctic Health Risks: Impacts on health in the Arctic and Europe owing to climate-induced changes in contaminant cycling. Human Health effects of contaminants and the influence of climate change (Work Package 4) EU-FP7-ENV-2008-1, Grant agreement: 226534.
  • From in vitro studies of environmental pollutants towards human health risk assessment
  • Reactive metabolites in early drug development: predictive in vitro tools
  • Food-drug interactions: exploring and pre-empting intricate health risks
  • Drug metabolizing genes and contaminants – modulation, mechanistic and health consequences.
  • Metabolism and interactions of pesticides in human and animal in vitro hepatic models.

Conferences and meetings

  • 2018 - UArctic Congress, Oulu and Helsinki, Finland
  • 2018 - 17th International Congress of Circumpolar Health, ICCH17, Copenhagen, Denmark
  • 2018 - 5th European Conference on Permafrost (EUCOP 2018) Chamonix-Mont Blanc, France
  • 2017- 47th Arctic Monitoring and Assessment Programme, Human Health Assessment Group, Ivalo, Finland
  • 2017- Joint Arctic Agenda, Luleå, Sweden
  • 2016- Society of Toxicology 55th Annual meeting and ToxExpo, New Orleans, USA
  • 2015- American College of Toxicology 36th Annual Meeting, Summerlin, Nevada/USA
  • 2014- Arctic Frontiers, Humans in the Arctic, Tromsø/Norway
  • 2013- The International Fresenius Conference "Food Safety and Dietary Risk Assessment", Mainz/Germany
  • 2012- 8th International Kastelli Symposium on New Challenges for Northern Environmental Research Oulu, Finland
  • 2011- Scandinavian Society of Cell Toxicology ‘’Towards toxicity assessment without animal’’, Tampere, Finland
  • 2011- CELLTOX Twenty years of in Vitro Toxicology: Achievements and Future Challenges, Rome, Italy
  • 2010- International Society for the Study of Xenobiotic (ISSX meeting), Istanbul, Turkey
  • 2009- 12th International Conference on Chemistry and the Environment, Stockholm, Sweden.
  • 2008- 15th International Congress on In Vitro Toxicology, Stockholm, Sweden
  • 2008- 18th International Mass Spectrometry Conference, Bremen, Germany
  • 2008- 5th European Conference on Pesticides and Related Organic Micropollutants in the Environment and the 11th Symposium on Chemistry and Fate of Modern Pesticides, Marseille, France
  • 2008- Scandinavian Physiological Society annual meeting, Oulu, Finland
  • 2007- REACH and AMAP, in silico-methods in toxicology International Congress, Oulu, Finland

Additional Trainings

  • 2018 - Health risk assessment of reproductive toxicity and endocrine disruptors - Karolinska Institutet, Stockholm, Sweden
  • 2017- Environmental Toxicology, Bangkok, Thailand
  • 2016- International Training Course on Environmental and Human Health Risk Assessment and Risk Management of Toxic Chemicals, Bangkok, Thailand
  • 2015- Juvenile Toxicity Studies, Defining, and Overcoming the Challenges, American College of Toxicology, USA
  • 2015- Selection and Use of Non-Rodent Species for Nonclinical Safety Assessment—Benefits, Pitfalls, and Caveats, American College of Toxicology, USA
  • 2013- Computer modeling of toxicokinetics and cellular signaling pathways, Karolinska Institute,Stockholm, Sweden
  • 2012- Health Risk Assessment – principles and applications, Karolinska Institute, Stockholm, Sweden
  • 2012- Modelling the impact of global climate change on the environmental fate of organic substances, Stockholm, Sweden
  • 2010- Competence to perform animal experiments in Finland according to Finnish legislation on animal experiments and the recommendations of the Federation of European Laboratory Animal Science Association (FELASA)- Finland

Selected publications

  • Abass, K.; Emelyanova, A.; Rautio, A. (2018) Temporal trends of contaminants in Arctic human populations. - Environmental science and pollution research 25 (29), 28834-28850 . [Original]
  • Adlard, B.; Donaldson, S. G.; Odland, J. O.; Weihe, P.; Berner, J.; Carlsen, A.; Bonefeld-Jorgensen, E. C.; Dudarev, A. A.; Gibson, J. C.; Krummel, E. M.; Olafsdottir, K.; Abass, K.; Rautio, A.; Bergdahl, I. A.; Mulvad, G. (2018) Future directions for monitoring and human health research for the Arctic Monitoring and Assessment Programme. - Global Health Action 11 (1), 1480084 . [Original]
  • Waits, A.; Emelyanova, A.; Oksanen, A.; Abass, K.; Rautio, A. (2018) Human infectious diseases and the changing climate in the Arctic. - Environment international 121 (1), 703-713 . [Original]
  • Abass, K.; Huusko, A.; Knutsen, H. K.; Nieminen, P.; Myllynen, P.; Meltzer, H. M.; Vahakangas, K.; Rautio, A. (2018) Quantitative estimation of mercury intake by toxicokinetic modelling based on total mercury levels in humans. - Environment international 114, 1-11 . [Original]
  • Palaniswamy, Saranya; Piltonen, Terhi; Koiranen, Markku; Mazej, Darja; Järvelin, Marjo-Riitta; Abass, Khaled; Rautio, Arja; Sebert, Sylvain (2018) The association between blood copper concentration and biomarkers related to cardiovascular disease risk – analysis of 206 individuals in the Northern Finland Birth Cohort 1966. - Journal of Trace Elements in Medicine and Biology 51, 12-18 . [Original]
  • Abass, Khaled; Carlsen, Anders; Rautio, Arja (2016) Arctic monitoring and assessment program : New approaches in human health risk assessment. - International journal of circumpolar health 75 (-), 33845 . [Original]
  • Abass, K.; Koiranen, M.; Mazej, D.; Tratnik, J.S.; Horvat, M.; Hakkola, J.; Järvelin, M.R.; Rautio, A. (2017) Arsenic, cadmium, lead and mercury levels in blood of Finnish adults and their relation to diet, lifestyle habits and sociodemographic variables. - Environmental science and pollution research 24 (2), 1347-1362 . [Original]
  • Elsebai, Mahmoud Fahmi; Abass, Khaled; Hakkola, Jukka; Atawia, Ahmed Rezk; Farag, Mohamed A. (2016) The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. - Food & function 7 (7), 3006-3016 . [Original]
  • Pelkonen, Olavi; Pasanen, Markku; Tolonen, Ari; Koskinen, Mikko; Hakkola, Jukka; Abass, Khaled; Laine, Jaana; Hakkinen, Merja; Juvonen, Risto; Auriola, Seppo; Storvik, Markus; Huuskonen, Pasi; Rousu, Timo; Rahikkala, Maiju (2015) Reactive metabolites in early drug development: predictive in vitro tools. - Current medicinal chemistry 22 (4), 538-550 . [Original]
  • Carlsson, Pernilla; Breivik, Knut; Brorström-Lunden, Eva; Cousins, Ian; Christensen, Jesper; Grimalt, Joan O.; Halsall, Crispin; Kallenborn, Roland; Abass, Khaled; Lammel, Gerhard; Munthe, John; MacLeod, Matthew; Odland, Jon Oyvind; Pawlak, Janet; Rautio, Arja; Reiersen, Lars-Otto; Schlabach, Martin; Stemmler, Irene; Wilson, Simon; Wöhrnschimmel, Henry (2018) Polychlorinated biphenyls (PCBs) as sentinels for the elucidation of Arctic environmental change processes: a comprehensive review combined with ArcRisk project results. - Environmental science and pollution research 25 (23; SI), 22499-22528 . [Original] [Self-archived]
  • Abass, Khaled M. (2016) An investigation into the formation of tebufenozide's toxic aromatic amine metabolites in human in vitro hepatic microsomes. - Pesticide Biochemistry and Physiology 133, 73-78 . [Original]
  • Nieminen, Pentti; Abass, Khaled; Vähäkangas, Kirsi; Rautio, Arja (2015) Statistically Non-significant Papers in Environmental Health Studies included more Outcome Variables. - Biomedical and Environmental Sciences 28 (9), 666-673 . [Original]
  • Abass, Khaled; Reponen, Petri; Mattila, Sampo; Rautio, Arja; Pelkonen, Olavi (2013) Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models. - Toxicology letters 224 (2), 300-309 . [Original]
  • Abass, Khaled; Reponen, Petri; Mattila, Sampo; Rautio, Arja; Pelkonen, Olavi (2014) Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomal model and its implications for chemical risk assessment. - Toxicology letters 224 (2), 290-299 . [Original]
  • Abass, Khaled; Huusko, Antti; Nieminen, Pentti; Myllynen, Päivi; Pelkonen, Olavi; Vähäkangas, Kirsi; Rautio, Arja (2013) Estimation of health risk by using toxicokinetic modeling: a case study of polychlorinated biphenyl PCB153. - Journal of hazardous materials 261, 1-10
  • Abass, Khaled (2013) From in vitro hepatic metabolic studies towards human health risk assessment: Two case studies of diuron and carbosulfan. - Pesticide Biochemistry and Physiology 107 (2), 258-265 . [Original]
  • Abass, Khaled M.; Abd-El-Razik, M.; Abouelghar, G. (2015) Fate and disposition of chlorpyrifos in human. Chlorpyrifos: Toxicological Properties, Uses and Effects on Human Health and the Environment. Mayes, Caitlin. - Ei sarjaa/No series. New York, NY. 167-188
  • Pelkonen, Olavi; Abass, Khaled; Wiesner, Jacqueline (2013) Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment. - Regulatory Toxicology and Pharmacology 65 (1), 100-107
  • Pelkonen, Olavi; Turpeinen, Miia; Hakkola, Jukka; Abass, Khaled; Pasanen, Markku; Raunio, Hannu; Vähäkangas, Kirsi (2013) Preservation, induction or incorporation of metabolism into the in vitro cellular system - views to current opportunities and limitations. - Toxicology in vitro 27, 1578-1583 . [Original]
  • Abass, Khaled; Pelkonen, Olavi (2013) The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches. - Toxicology in vitro 27, 1584-1588 . [Original]
  • Khaled Abass; Miia Turpeinen; Arja Rautio; Jukka Hakkola; Olavi Pelkonen (2011) Metabolism of pesticides by human cytochrome P450 enzyems in vitro - a survey. Insecticides - Advances in Integrated Pest Management. Farzana Perveen. 165-194, 8. [Original]
  • Abass K; Lämsä V; Reponen P; Küblbeck J; Honkakoski P; Mattila S; Pelkonen O; Hakkola J (2012) Characterization of human cytochrome P450 induction by pesticides. - Toxicology 294 (1), 17-26 . [Original]
  • Abass K., Reponen P., Mattila S., Pelkonen O. (2011) Metabolism of α-thujone in human hepatic preparations in vitro. - Xenobiotica 41 (2), 101-111
  • Sevior DK, Hokkanen J, Tolonen A, Abass Khaled, Tursas Larissa, Pelkonen Olavi, Ahokas JT (2010) Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail. - Xenobiotica 40, 245-254 . [Original]
  • Abass K, Reponen P, Mattila S, Pelkonen O (2009) Metabolism of carbosulfan. I. Species differences in the in vitro biotransformation by mammalian hepatic microsomes including human. - Chemico-Biological interaction 181, 210-219
  • Abass Khaled, Reponen Petri, Mattila Sampo, Pelkonen Olavi (2010) Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. - Chemico-biological interactions 185, 163-173
  • Reponen Petri, Abass Khaled, Mattila Sampo, Pelkonen Olavi (2010) Overview of the metabolism and interactions of pesticides in hepatic in vitro systems. - International journal of environmental analytical chemistry 90, 429-437 . [Original]
  • Abass Khaled, Reponen Petri, Turpeinen Miia, Mattila Sampo, Pelkonen Olavi (2010) Do cytochrome P450 enzymes contribute to the metabolism of xenobiotics in human?. Fungicides. Odile Carisse (ed.), InTech. 441-468. [Original]
  • Abass K, Turpeinen M, Pelkonen O (2009) Evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. - Journal of Environmental Science and Health Part B 44, 553-563
  • Abass, Khaled; Reponen, Petri; Turpeinen, Miia; Jalonen, Jorma & Pelkonen, Olavi (2007) Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. - Drug metabolism and disposition 35, 1634-1641
  • Abass, Khaled; Reponen, Petri; Jalonen, Jorma & Pelkonen, Olavi (2007) In vitro metabolism and interaction of profenofos by human, mouse and rat liver preparations. - Pesticide Biochemistry and Physiology 87, 238-247
  • Abass, Khaled; Reponen, Petri; Jalonen, Jorma & Pelkonen, Olavi (2007) In vitro metabolism and interactions of the fungicide metalaxyl in human liver preparations. - Environmental toxicology and pharmacology 23, 39-47
  • Abass, Khaled M.; Abd-El-Razik, M.; Abouelghar, G. (2015) Fate and disposition of chlorpyrifos in human. Chlorpyrifos: Toxicological Properties, Uses and Effects on Human Health and the Environment. Mayes, Caitlin. - Ei sarjaa/No series. New York, NY. 167-188
  • Khaled Abass; Miia Turpeinen; Arja Rautio; Jukka Hakkola; Olavi Pelkonen (2011) Metabolism of pesticides by human cytochrome P450 enzyems in vitro - a survey. Insecticides - Advances in Integrated Pest Management. Farzana Perveen. 165-194, 8. [Original]
  • Abass Khaled, Reponen Petri, Turpeinen Miia, Mattila Sampo, Pelkonen Olavi (2010) Do cytochrome P450 enzymes contribute to the metabolism of xenobiotics in human?. Fungicides. Odile Carisse (ed.), InTech. 441-468. [Original]
  • Abass K, Reponen P, Pelkonen O (2009) Metabolic and interaction properties of selected fungicides. Fungicides. Chemistry, Environment Impact and Health Effects. De Costa P, Bezerra P (eds.). 25-62