Molecular Physiology

Research group information

Contact information

Research group leader

  • Professor
    Karl-Heinz Herzig

Research group description

Many diseases are related to unequal input/output balance, imbalance/lack of macronutrients, toxic compounds or physical inactivity. The different organs involved in keeping homeostasis (brain-gut/microbiome-fat-liver-muscle) are tightly communicating with each other via peptides, proteins, nutrients and nerves (adipokines, hepatokines, myokines, gut peptides, neurotransmitters). Understanding the communication of this organ cross talk might decipher the molecular mechanisms in the pathogenesis of metabolic diseases like diabetes and obesity/metabolic syndrome. Furthermore, the increased energy storages lead to inflammation affecting the signaling cascades. Our mission is to elucidate the communication signals and pathways which might lead to novel therapeutic targets and new strategies for the prevention of these diseases.

Our team

  • Juhani Leppäluoto, Prof. em. hc.
  • Kari Mäkelä, PhD
  • Miia Kovalainen, PhD
  • Laura Niiranen, MSc
  • Ghulam Shere Raza, MSc
  • Toni Karhu; MSc
  • Shivaprakash Jagalur Mutt, MSc
  • Dominique Gagnon, MSc
  • Meeri Kröger, technician

Where are we headed

We currently are focusing on inflammatory /signaling markers in relation to metabolic regulation and cardiovascular risk assessment in subject with metabolic syndrome and to conduct activity interventions in those subjects/myokines. On the cellular level we try to elucidate the molecular mechanisms of inflammation in the adipose tissue.

How to find us

karl-heinz.herzig[at]oulu.fi