Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort.

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Auditorium 1, PT1 108, Research Unit of Clinical Neuroscience, Peltolantie 17, Building PT1, FIN-90220, Oulu, Finland.

Topic of the dissertation

Alcohol use, alcohol polygenic score and cognition in schizophrenia, schizoaffective disorder, bipolar disorder, and a middle-aged birth cohort.

Doctoral candidate

PhD student Atiqul Mazumder

Faculty and unit

University of Oulu Graduate School, Faculty of Medicine, Research Unit of Clinical Neuroscience

Subject of study

Psychiatry

Opponent

Professor Soili Lehto, University of Oslo, Norway

Custos

Professor Juha Veijola, University of Oulu

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Alcohol use and cognitive functions in psychotic patients.

Self-reported alcohol use was not associated with poorer cognition in schizophrenia and bipolar disorder patients. On the other hand, alcohol use disorder was associated with poor cognition in patients with psychotic disorder. Alcohol polygenic score was not associated with cognition in schizophrenia or bipolar disorder patients.

The aim of the study was to investigate the association between alcohol use, alcohol use disorder, and polygenic risk of alcohol use and cognition in patients with psychotic disorder. The psychiatric patients included 10,417 participants who had a clinical diagnosis of schizophrenia or bipolar disorder.

Our results suggest that moderate alcohol use might not be harmful for cognition in patients with psychotic disorder. However, the findings should be interpreted cautiously, and no clinical conclusions can be drawn until the results of this study are replicated in other studies.
Last updated: 27.9.2022