Association of one-hour post-load glucose in an oral glucose tolerance test with type 2 diabetes and its related complications
Thesis event information
Date and time of the thesis defence
Place of the thesis defence
Leena Palotie auditorium
Topic of the dissertation
Association of one-hour post-load glucose in an oral glucose tolerance test with type 2 diabetes and its related complications
Doctoral candidate
Licentiate of Medicine Anni Saunajoki
Faculty and unit
University of Oulu Graduate School, Faculty of Medicine, Research Unit of Population Health
Subject of study
Medicine
Opponent
Associate Professor Merja Laine, University of Helsinki
Custos
Professor Juha Auvinen, University of Oulu
One-hour post-load glucose in an oral glucose tolerance test is a useful method for identifying people at high risk for type 2 diabetes and its related complications
One-hour post-load glucose in an oral glucose tolerance test is a capable method for identifying individuals at high risk of developing type 2 diabetes and diabetes-related complications. Early detection of people at high risk of type 2 diabetes allows interventions that may delay or prevent the onset of type 2 diabetes and related complications. The previously accepted methods for diagnosing type 2 diabetes and prediabetes are fasting glucose, 2-hour post-load glucose in an oral glucose tolerance test and long-term blood glucose HbA1c. However, 2-hour oral glucose tolerance test has been considered time-consuming, and thus 1-hour post-load glucose in an oral glucose tolerance test has risen in interest.
The aim of this thesis was to investigate the association of 1-hour post-load glucose with type 2 diabetes and its related complications. Four Finnish study populations were used for the analyses of the present thesis. The value of 1-hour post-load glucose measurement was compared with current diagnostic methods.
The results revealed that one-hour post-load glucose was a better predictor of type 2 diabetes and cardiovascular events than fasting or 2-hour post-load glucoses. Elevated 1-hour post-load glucose was associated with retinopathy signs and elevated levels of albumin in urine, but no such an association was seen in fasting glucose, 2-hour post-load glucose and HbA1c. Furthermore, the 2-hour post-load glucose did not provide any benefit in addition to fasting and 1-hour post-load glucoses in the prediction of type 2 diabetes and its related complications.
In conclusion, these results together with previous findings indicate that the use of 1-h post-load glucose and shortened 1-hour oral glucose tolerance test seems reasonable to consider in the future. Shortening the 2-hour oral glucose tolerance test to 1 hour would likely improve its acceptability in practice as it would be more timesaving and patient-friendly than 2-hour oral glucose tolerance test.
The aim of this thesis was to investigate the association of 1-hour post-load glucose with type 2 diabetes and its related complications. Four Finnish study populations were used for the analyses of the present thesis. The value of 1-hour post-load glucose measurement was compared with current diagnostic methods.
The results revealed that one-hour post-load glucose was a better predictor of type 2 diabetes and cardiovascular events than fasting or 2-hour post-load glucoses. Elevated 1-hour post-load glucose was associated with retinopathy signs and elevated levels of albumin in urine, but no such an association was seen in fasting glucose, 2-hour post-load glucose and HbA1c. Furthermore, the 2-hour post-load glucose did not provide any benefit in addition to fasting and 1-hour post-load glucoses in the prediction of type 2 diabetes and its related complications.
In conclusion, these results together with previous findings indicate that the use of 1-h post-load glucose and shortened 1-hour oral glucose tolerance test seems reasonable to consider in the future. Shortening the 2-hour oral glucose tolerance test to 1 hour would likely improve its acceptability in practice as it would be more timesaving and patient-friendly than 2-hour oral glucose tolerance test.
Last updated: 23.1.2024