Development of inhibitors for potential drug targets - human ADP ribosyltransferases
Thesis event information
Date and time of the thesis defence
Place of the thesis defence
Auditorium F101 of the Faculty of Biochemistry and Molecular Medicine (Aapistie 7), Zoom link: https://oulu.zoom.us/j/68257495343?pwd=eDBOMlg2dkNwbW5IMXZJTFN5b01Bdz09
Topic of the dissertation
Development of inhibitors for potential drug targets - human ADP ribosyltransferases
Doctoral candidate
Master of Science Sudarshan Narasimha Murthy
Faculty and unit
University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, Protein and Structural Biology Research Unit
Subject of study
Biochemistry and Molecular Medicine
Opponent
Adj. Professor Tiina Salminen, Åbo Akademy University
Custos
Professor Lari Lehtiö, University of Oulu
Development of inhibitors for potential drug targets - human ADP ribosyltransferases
This study focuses on the development of small-molecule inhibitors towards two ADP ribosyltransferases, ARTD10 and ARTD7. Human ADP-ribosyltransferases are enzymes which are involved in several cellular processes and are potential targets for drug development. To verify the roles of the enzymes, a high-quality inhibitor, inhibiting the enzymes specifically, is needed.
The dissertation used biochemical and structural biological methods to investigate the binding of various small molecules to ARTD enzymes. Based on this, a new inhibitor was developed for ARTD10 with better potency than previous inhibitors. The developed inhibitor can now be used as a research tool to study the function of ARTD10 in cells.
The dissertation also laid the foundation for the selective inhibition of the ARTD7 enzyme, which will be useful for future studies to help determine the effect of enzyme activity on, for example, various cancer cells.
The dissertation used biochemical and structural biological methods to investigate the binding of various small molecules to ARTD enzymes. Based on this, a new inhibitor was developed for ARTD10 with better potency than previous inhibitors. The developed inhibitor can now be used as a research tool to study the function of ARTD10 in cells.
The dissertation also laid the foundation for the selective inhibition of the ARTD7 enzyme, which will be useful for future studies to help determine the effect of enzyme activity on, for example, various cancer cells.
Last updated: 1.3.2023