GDAP1: Relationship to inherited polyneuropathies from a structural perspective
Thesis event information
Date and time of the thesis defence
Place of the thesis defence
Faculty of Biochemistry and Molecular medicine, lecture hall F101
Topic of the dissertation
GDAP1: Relationship to inherited polyneuropathies from a structural perspective
Doctoral candidate
MSc Aleksi Sutinen
Faculty and unit
University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, Protein and structural biology
Subject of study
Biokemia
Opponent
Professor Julia Edgar, University of Glasgow
Custos
Professor Petri Kursula, University of Oulu
Structural properties of GDAP1 protein and implications in Charcot-Marie-Tooth syndrome
The PhD-thesis covers investigation of structural properties of GDAP1 protein. GDAP1 is a mebrane protein expressed in neurons, spesifically the mitochondrial outer membrane. The protein is involved in maintaining mitochondrial functions and known to participate in mitochondrial division. Mutations into the GDAP1 gene are known to cause Charcot-Marie-Tooth syndrome, a disease leading to malfunction of neurons. The objective of this study was to utilize methods used in structural biology such as macromolecular crystallography and small-angle x-ray scattering in search of the protein function and pathophysiological relationship.
Last updated: 23.1.2024