Modulation of connective tissue growth factor and activin receptor 2B function in cardiac hypertrophy and fibrosis

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Leena Palotie auditorium 101A

Topic of the dissertation

Modulation of connective tissue growth factor and activin receptor 2B function in cardiac hypertrophy and fibrosis

Doctoral candidate

Master of Science Zoltan Szabo

Faculty and unit

University of Oulu Graduate School, Faculty of Medicine, Research Unit of Biomedicine

Subject of study

Biomedicine

Opponent

Professor Antti Saraste, Heart Center, Turku University Hospital

Custos

Professor Risto Kerkelä, University of Oulu, Faculty of Medicine, Research Unit of Biomedicine

Add event to calendar

MODULATION OF CONNECTIVE TISSUE GROWTH FACTOR AND ACTIVIN RECEPTOR 2B FUNCTION IN CARDIAC HYPERTROPHY AND FIBROSIS

The increase of cardiac hemodynamic load that requires increased mechanical performance drives adaptation of the heart to maintain cardiac function. Modification of protein synthesis in cardiomyocytes allows the cells to adapt to the increased load. Cardiomyocyte hypertrophy and activation of cardiac fibroblasts over the long term is maladaptive and leads to heart failure (HF). Understanding the complex and converging pathways regulating cardiac remodeling is a major challenge, but it may allow for opportunities to develop new therapies, new medicines and provide new hope for people with these life-threatening diseases.
Last updated: 20.9.2019