Multilayered polyelectrolyte assemblies as a delivery system for biomedical applications.

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

L10, remote connection: https://oulu.zoom.us/j/67408287658

Topic of the dissertation

Multilayered polyelectrolyte assemblies as a delivery system for biomedical applications.

Doctoral candidate

Master of Science Iana Tarakanchikova

Faculty and unit

University of Oulu Graduate School, Faculty of Information Technology and Electrical Engineering, Optoelectronics and Measurement Techniques (OPEM)

Subject of study

Electrical engineering

Opponent

Dr. rer. nat. Vladimir Sivakov, Leibniz Institute of Photonic Technology, Germany

Second opponent

FT Anton Sadovoy, Institute of Materials Research and Engineering, Singapore

Custos

Research Professor Alexey Popov, VTT Technical Research Center of Finland

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Novel drug delivery system for nanomedical applications

This thesis presents the results of the development of a new gene delivery system, based on polymer capsules with subsequent optical characterization in vitro and in vivo. The biggest advantages of biodegradable polymer capsules compared to other non-viral carriers include their superior loading capacity, low toxicity, size control and high colloidal stability. Polymer capsules have great advantages for application in gene therapy. An efficient delivery system is the main component for the successful introduction of a gene therapy into real clinical practice.

A preliminary conclusion of the current study is that biocompatible polyelectrolyte capsules can be efficiently used for the delivery of biologically active compounds to many types of cells including transfection-resistant target cells. The obtained data ensures that biodegradable capsules will endure not only as an ultimate tool for transferring nucleic acid for in vitro systems but that they can also be used for the development of novel treatments for patients requiring routine drug administration.
Last updated: 28.10.2021