The role of antidiabetic medication, statins, and menopausal hormone therapy in breast cancer among women with type 2 diabetes

Breast cancer is globally the most diagnosed cancer and a leading cause of death among the female population worldwide. The risk of breast cancer is increased by approximately 20% in women with type 2 diabetes (T2D).
We aimed to investigate whether metformin and/or statins use is associated with reduced incidence and mortality in breast cancer patients with T2D. Additionally, we wanted to see if there is association between the use of these medications and prevalence of two main histological subtypes of breast cancer, invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) in women with T2D. We investigated whether menopausal hormone therapy use is associated with a reduced breast cancer mortality in women with T2D.