Sudden death due to non-ischemic myocardial diseases. Genetics and electrocardiographic characteristics

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Oulu University Hospital, lecture hall 8. Remote access: https://oulu.zoom.us/j/63415040970

Topic of the dissertation

Sudden death due to non-ischemic myocardial diseases. Genetics and electrocardiographic characteristics

Doctoral candidate

Licentiate of Medicine Lauri Holmström

Faculty and unit

University of Oulu Graduate School, Faculty of Medicine, Research Unit of Internal Medicine, MRC Oulu

Subject of study

Cardiology

Opponent

Professor Johanna Kuusisto, University of Eastern Finland and Kuopio University Hospital

Custos

Professor Juhani Junttila, University of Oulu and Oulu University Hospital

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Genetic background and electrocardiographic characteristics of sudden death due to non-ischemic myocardial diseases

In this thesis dissertation, we noticed that sudden death due to non-ischemic myocardial diseases may associate with gene defects more often than previously thought, and that such myocardial diseases may express ECG abnormalities prior to sudden death.

Previous studies have focused on inherited cardiomyopathies that cause sudden deaths mainly in young, whereas genetic background and electrocardiographic characteristics of sudden death victims with unspecific or apparently acquired non-ischemic myocardial disease is less well known.

The study population was based on the Fingesture study which has gathered data from almost 6,000 sudden cardiac death victims in Northern Finland since 1998. Genetic and ECG analyses were focused on the victims with non-ischemic myocardial disease at autopsy. Classification of genetic variants was based on consensus guidelines and ECG characteristics were compared to both autopsy findings and general population.

The incidence of sudden cardiac death is approximately 0.1-0.2% annually, and about 20% are due to non-ischemic myocardial diseases. Sudden cardiac death is often the first manifestation of the underlying heart disease. Therefore, early identification of the disease is important and search for novel risk factors continues to be an important research area.
Last updated: 10.8.2020