Antti Koskela

MD, PhD

University Teacher, physician
Bone toxicology, bone health

28 peer reviewed publications in international journals. The publications have been cited 374 times, of which the most cited publication accounts for 146 citations. The author has a h-index of 13.00. (Scopus)

Biography

I study how environmental chemicals affect our bone tissue, the current main focus being perfluorinated compounds and microbial toxins. In addition, I have studied dioxins and organotin compounds. One focus area is how simultaneous exposure to different environmental chemicals affect our health, since we all have our individual environmental chemical cocktail in our bodies. Bone is a potential target for environmental chemicals, and bone remodelation (resorption and formation) continue throughout the life on an individual, which makes it an interesting tissue from toxicology point of view. The methodology comprises of cell culturing, measurements on cellular level, imaging and biomechanical studies. I also collaborate with epidemiologists from countries such as USA, and one focus is to study environmental chemical exposure on epidemiological level.

 

I teach the human anatomy for medical and dental medicine students and work as a patient-caring physician in the city of Oulu. I also do pedagogical research and study the best ways of teaching the human anatomy and cell biology for future medical experts.

Research interests

  • Environmental chemicals and bone
  • Bone cell biology
  • Bone as a container for environmental chemicals
  • Environmental chemicals
  • Persistent Organic Pollutants

Teaching

040101A Anatomy, 043010P Medical Cell Biology

Selected publications

  • Koskela, A.; Koponen, J.; Lehenkari, P.; Viluksela M.; Korkalainen, M.; Tuukkanen, J. (2017) Perfluoroalkyl substances in human bone: concentrations in bones and effects on bone cell differentiation.. - Scientific Reports 7 (1), 6841 . [Original]
  • Koskela, Antti (2016) Bone as a target for persistent organic pollutants. - Acta Universitatis Ouluensis. Series D, Medica 1399. Oulu. Artikkeliväitöskirja. 84. [Original]
  • Koskela, A.; Finnilä, M. A.; Korkalainen, M.; Spulber, S.; Koponen, J.; Hakansson, H.; Tuukkanen, J.; Viluksela, M. (2016) Effects of developmental exposure to perfluorooctanoic acid (PFOA) on long bone morphology and bone cell differentiation. - Toxicology and applied pharmacology 301, 14-21 . [Original]
  • Koskela, Antti; Viluksela, Matti; Keinänen, Meeri; Tuukkanen, Juha; Korkalainen, Merja (2012) Synergistic effects of tributyltin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on differentiating osteoblasts and osteoclasts. - Toxicology and applied pharmacology 263, 210-217
  • Moverare-Skrtic, Sofia; Henning, Petra; Liu, Xianwen; Nagano, Kenichi; Saito, Hiroaki; Borjesson, Anna E.; Sjogren, Klara; Windahl, Sara H.; Farman, Helen; Kindlund, Bert; Engdahl, Cecilia; Koskela, Antti; Zhang, Fu-Ping; Eriksson, Emma E.; Zaman, Farasat; Hammarstedt, Ann; Isaksson, Hanna; Bally, Marta; Kassem, Ali; Lindholm, Catharina; Sandberg, Olof; Aspenberg, Per; Savendahl, Lars; Feng, Jian (2014) Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. - Nature Medicine 20 (11), 1279-1288
  • Ohlsson C; Engdahl C; Börjesson AE; Windahl SH; Studer E; Westberg L; Eriksson E; Koskela A; Tuukkanen J; Krust A; Chambon P; Carlsten H; Lagerquist MK (2012) Estrogen receptor-alpha expression in neuronal cells affects bone mass. - Proceedings of the National Academy of Sciences of the United States of America 109 (3), 983-988 . [Original]
  • Windahl, Sara H.; Börjesson, Anna E.; Farman, Helen H; Engdahl, Cecilia; Movérare-Skrtic, Sofia; Sjögren, Klara; Lagerquist, Marie K.; Kindblom, Jenny M.; Koskela, Antti; Tuukkanen, Juha; Divieti Pajevic, Paola; Feng, Jian Q.; Dahlman-Wright, Karin; Antonson, Per; Gustafsson, Jan-Åke; Ohlsson, Claes (2013) Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice. - Proceedings of the National Academy of Sciences of the United States of America 110 (6), 2294-2299 . [Original]
  • Strandgren, Charlotte; Nasser, Hasina Abdul; McKenna, Tomas; Koskela, Antti; Tuukkanen, Juha; Ohlsson, Claes; Rozell, Björn; Eriksson, Maria (2015) Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects. - FASEB Journal 29 (8), 3193-3205 . [Original]
  • Moverare-Skrtic, Sofia; Wu, Jianyao; Henning, Petra; Gustafsson, Karin L.; Sjögren, Klara; Windahl, Sara H.; Koskela, Antti; Tuukkanen, Juha; Börjesson, Anna E.; Lagerquist, Marie K.; Lerner, Ulf H.; Zhang, Fu-Ping; Gustafsson, Jan-Ake; Poutanen, Matti; Ohlsson, Claes (2015) The bone-sparing effects of estrogen and WNT16 are independent of each other. - Proceedings of the National Academy of Sciences of the United States of America 112 (48), 14972-14977