Sylvain Sebert

Sylvain Sebert

Biography

Research Group: Developmental and Life-Course Epidemiology

Together with Marjo-Riitta Järvelin (scientific director of the NFBC), I am leading a multicultural team of researchers to study the life-course trajectories to unhealthy ageing via the alteration of cardio-metabolic functions. 

We combine various source of data from the fetal period until old age via exciting collaborations with international research consortia (The Pregancy And Childhood Epigenetic, PACE ; and the Early Growth Genetic Consortium, EGG) and European projects we are parnter in: LifeCyle or coordinating: DynaHEALTH.

The group uses genomics, epigenomics, telomeric and biological data combined to psychosocial factors at key stages of the life-course to establish how alterations of the metabolic environemnt (fetal hypoxia, fetal glucose, fetal stress) can be prevented by parental healthcare (prevention of maternal anemia, gestational diabetes, obesity and social deprivation) or modulated by early life interventions. 

We also collect new data accross generations to study the transgenerational transmission of health via (epi)genetic and social pathways.   

Research interests

  • Body weight regulation
  • Life-course models
  • Dynamic of health
  • Research training

Group members

  • Nina Rautio 
  • Estelle Lowry 
  • Justiina Ronkainen 
  • Rozenn Nedelec 
  • Saranya Palaniswamy 
  • Priyanka Parmar 
  • Anni Heiskala 
  • Mimmi Tolvanen 
  • Tuulia Varanka-Ruuska 
  • Sanna Papunen 
  • Anna Mustakallio 
  • Helmi Ikonen 
  • Eeva Sliz
  • Iiro Nerg 

Recruitment - contact

Follow us on twitter and linkedin

It is always a pleasure to discuss new opportunity for PhD projects

Databases

Research groups

  • Project leader , Center for Life Course Epidemiology and Systems Medicine

Selected publications

  • Ronkainen, Justiina; Huusko, Tuija J.; Soininen, Raija; Mondini, Eleonora; Cinti, Francesca; Mäkelä, Kari A.; Kovalainen, Miia; Herzig, Karl-Heinz; Järvelin, Marjo-Riitta; Sebert, Sylvain; Savolainen, Markku J.; Salonurmi, Tuire (2015) Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue. - Scientific Reports 5, 9233 . [Original]
  • Tyrrell, Jessica; Richmond, Rebecca C.; Palmer, Tom M.; Feenstra, Bjarke; Rangarajan, Janani; Metrustry, Sarah; Cavadino, Alana; Paternoster, Lavinia; Armstrong, Loren L.; De Silva, N. Maneka G.; Wood, Andrew R.; Horikoshi, Momoko; Geller, Frank; Myhre, Ronny; Bradfield, Jonathan P.; Kreiner-Moller, Eskil; Huikari, Ville; Painter, Jodie N.; Hottenga, Jouke-Jan; Allard, Catherine (2016) Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. - JAMA : the journal of the American Medical Association 315 (11), 1129-1140 . [Original] [Self-archived]
  • Horikoshi, M.; Beaumont, R.N.; Day, F.R.; Warrington, N.M.; Kooijman, M.N.; Fernandez-Tajes, J.; Feenstra, B.; van Zuydam, N.R.; Gaulton, K.J.; Grarup, N.; Bradfield, J.P.; Strachan, D.P.; Li-Gao, R.; Ahluwalia, T.S.; Kreiner, E.; Rueedi, R.; Lyytikäinen, L.P.; Cousminer, D.L.; Wu, Y.; Thiering, E. (2016) Genome-wide associations for birth weight and correlations with adult disease. - Nature 538 (7624), 248-252 . [Original]
  • Mutt SJ; Karhu T; Lehtonen S; Lehenkari P; Carlberg C; Saarnio J; Sebert S; Hyppönen E; Järvelin MR; Herzig KH (2012) Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D3 via the NF-B pathway. - FASEB Journal 26 (11), 4400-4407 . [Original]
  • Williams, Dylan M.; Palaniswamy, Saranya; Sebert, Sylvain; Buxton, Jessica L.; Blakemore, Alexandra I. F.; Hyppoenen, Elina; Järvelin, Marjo-Riitta (2016) 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966. - American journal of epidemiology 183 (3), 191-198 . [Original] [Self-archived]
  • Rautio, Nina; Varanka-Ruuska, Tuulia; Vaaramo, Eeva; Palaniswamy, Saranya; Nedelec, Rozenn; Miettunen, Jouko; Karppinen, Jaro; Auvinen, Juha; Järvelin, Marjo-Riitta; Keinänen-Kiukaanniemi, Sirkka; Sebert, Sylvain; Ala-Mursula, Leena (2017) Accumulated exposure to unemployment is related to impaired glucose metabolism in middle-aged men : A follow-up of the Northern Finland Birth Cohort 1966. - Primary care diabetes 11 (4), 365-372 . [Original]
  • Palaniswamy, Saranya; Williams, Dylan; Järvelin, Marjo-Riitta; Sebert, Sylvain (2015) Vitamin D and the Promotion of Long-Term Metabolic Health from a Programming Perspective. - Nutrition and Metabolic Insights 8 (1), 11-21 . [Original] [Self-archived]
  • Palaniswamy, Saranya; Hyppönen, Elina; Williams, Dylan M.; Jokelainen, Jari; Lowry, Estelle; Keinänen-Kiukaanniemi, Sirkka; Herzig, Karl-Heinz; Järvelin, Marjo-Riitta; Sebert, Sylvain (2017) Potential determinants of vitamin D in Finnish adults : a cross-sectional study from the Northern Finland birth cohort 1966. - BMJ Open 7 (3), e013161 . [Original] [Self-archived]
  • Felix, Janine F. ; Bradfield, Jonathan P. ; Monnereau, Claire ; van der Valk, Ralf J. P. ; Stergiakouli, Evie ; Chesi, Alessandra ; Gaillard, Romy ; Feenstra, Bjarke ; Thiering, Elisabeth ; Kreiner-Moller, Eskil ; Mahajan, Anubha ; Pitkanen, Niina ; Joro, Raimo ; Cavadino, Alana ; Huikari, Ville ; Franks, Steve ; Groen-Blokhuis, Maria M. ; Cousminer, Diana L. ; Marsh, Julie A. ; Lehtimäki, Terho (2016) Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. - Human Molecular Genetics 25 (2), 389-403 . [Original]
  • Ronkainen, Justiina; Huusko, Tuija J.; Soininen, Raija; Mondini, Eleonora; Cinti, Francesca; Mäkelä, Kari A.; Kovalainen, Miia; Herzig, Karl-Heinz; Järvelin, Marjo-Riitta; Sebert, Sylvain; Savolainen, Markku J.; Salonurmi, Tuire (2015) Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue. - Scientific Reports 5, 9233 . [Original]