OASIS - Organ-on-chip platform for in situ detection of osteoarthritis biomarkers

OASIS aims to develop a biomimetic in vitro model of osteoarthritis (OA) building-on the preexisting and well-demonstrated bone marrow in vitro model from Finnadvance. These microfluidic models, appropriately termed as organ-on-chip (OoC), will allow for highly parallelized and replicable OA pathology simulation on standardized chip platform. Our approach also solves the second initiative of pre-emptive sensing by employing an integrated modular biochemical sensing platform based on carbon nanotube sensing elements coupled to electrochemical detection. This project advances preemptive predictive care and sensing methodologies, over the current postdiagnosis cures. Early detection is key for reduced burden from OA and OA-related health and economic losses globally.