Developmental Biology Laboratory: Organogenesis & Extracellular Vesicles

Our primary research foci are developmental biology and extracellular vesicles (EVs) and their function in human health and nature.
Vainio Research Group 2021
Vainio Research Group 2021

Research group information

Contact information

Research group leader

  • Research Unit leader
    Seppo Vainio

Contact person

Research group description

Our diverse research group works on a multitude of intertwined research projects in development and EVs with support from Finnish grantees and the European Union. We are always interested in new projects and collaborations. 

Research

Current issues

Media and Outreach Activities

Selected Publications

Our group has published over 160 peer-reviewed journal articles. Below are some examples to represent our research findings. Click here for a complete list of Prof. Vainio’s publications. 

  • Rak-Raszewska, A., Reint, G., Geiger, F., Naillat, F., & Vainio, S. J. (2021). Deciphering the minimal quantity of mouse primary cells to undergo nephrogenesis ex vivo. Developmental Dynamics: An Official Publication of the American Association of Anatomists. https://doi.org/10.1002/dvdy.418

  • Bart, G., Fischer, D., Samoylenko, A., Zhyvolozhnyi, A., Stehantsev, P., Miinalainen, I., Kaakinen, M., Nurmi, T., Singh, P., Kosamo, S., Rannaste, L., Viitala, S., Hiltunen, J., & Vainio, S. J. (2021). Characterization of nucleic acids from extracellular vesicle-enriched human sweat. BMC Genomics, 22(1), 425. https://doi.org/10.1186/s12864-021-07733-9

  • Ullah, M. S., Zhivonitko, V. V., Samoylenko, A., Zhyvolozhnyi, A., Viitala, S., Kankaanpää, S., Komulainen, S., Schröder, L., Vainio, S. J., & Telkki, V.-V. (2021). Identification of extracellular nanoparticle subsets by nuclear magnetic resonance. Chemical Science, 12(24), 8311–8319. https://doi.org/10.1039/d1sc01402a

  • Monteiro-Reis, S., Carvalho-Maia, C., Bart, G., Vainio, S. J., Pedro, J., Silva, E. R., Sales, G., Henrique, R., & Jerónimo, C. (2021). Secreted Extracellular Vesicle Molecular Cargo as a Novel Liquid Biopsy Diagnostics of Central Nervous System Diseases. International Journal of Molecular Sciences, 22(6), 3267. https://doi.org/10.3390/ijms22063267

  • Paul, T., Vainio, S., & Roning, J. (2021). Clustering and classification of virus sequence through music communication protocol and wavelet transform. Genomics, 113(1 Pt 2), 778–784. https://doi.org/10.1016/j.ygeno.2020.10.009

  • Veikkolainen, V., Ali, N., Doroszko, M., Kiviniemi, A., Miinalainen, I., Ohlsson, C., Poutanen, M., Rahman, N., Elenius, K., Vainio, S. J., & Naillat, F. (2020). Erbb4 regulates the oocyte microenvironment during folliculogenesis. Human Molecular Genetics, 29(17), 2813–2830. https://doi.org/10.1093/hmg/ddaa161

  • Perevedentseva, E., Ali, N., Lin, Y.-C., Karmenyan, A., Chang, C.-C., Bibikova, O., Skovorodkin, I., Prunskaite-Hyyryläinen, R., Vainio, S. J., Kinnunen, M., & Cheng, C.-L. (2020). Au nanostar nanoparticle as a bio-imaging agent and its detection and visualization in biosystems. Biomedical Optics Express, 11(10), 5872–5885. https://doi.org/10.1364/BOE.401462

  • Andjus, P., Kosanović, M., Milićević, K., Gautam, M., Vainio, S. J., Jagečić, D., Kozlova, E. N., Pivoriūnas, A., Chachques, J.-C., Sakaj, M., Brunello, G., Mitrecic, D., & Zavan, B. (2020). Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage. International Journal of Molecular Sciences, 21(18), E6859. https://doi.org/10.3390/ijms21186859

  • Ali, N., Rezvani, H. R., Motei, D., Suleman, S., Mahfouf, W., Marty, I., Ronkainen, V.-P., & Vainio, S. J. (2020). Trisk 95 as a novel skin mirror for normal and diabetic systemic glucose level. Scientific Reports, 10(1), 12246. https://doi.org/10.1038/s41598-020-68972-6

  • Kaisto, S., Saarela, U., Dönges, L., Raykhel, I., Skovorodkin, I., & Vainio, S. J. (2020). Optimization of Renal Organoid and Organotypic Culture for Vascularization, Extended Development, and Improved Microscopy Imaging. Journal of Visualized Experiments: JoVE, 157. https://doi.org/10.3791/60995

  • Tan, Z., Rak-Raszewska, A., Skovorodkin, I., & Vainio, S. J. (2020). Mouse Embryonic Stem Cell-Derived Ureteric Bud Progenitors Induce Nephrogenesis. Cells, 9(2). https://doi.org/10.3390/cells9020329

  • Karvinen, S., Sievänen, T., Karppinen, J. E., Hautasaari, P., Bart, G., Samoylenko, A., Vainio, S. J., Ahtiainen, J. P., Laakkonen, E. K., & Kujala, U. M. (2020). MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise. Frontiers in Physiology, 11, 676. https://doi.org/10.3389/fphys.2020.00676. Open access link

  • Tikka, P., Mercker, M., Skovorodkin, I., Saarela, U., Vainio, S. J., Marciniak-Czochra, A., Schaefer, F., Sluka, J. P., Glazier, J. A., & Ronkainen, V.-P. (2020). Computational Modelling of Cell Movements and Aggregations during Kidney Organogenesis. BioRxiv.

 

Recent Grants and Projects

Our projects are being supported by several funding agencies. Below is a list of our ongoing projects.

  • Academy of Finland, Wnt-mediated Kidney Tubule Induction – the Role of Secreted Extracellular Vesicles as Putative Morphogens    (Wnt and EVs), 2018-2022, 498.000 € 
  • EU FET OPEN, Next-generation theranostics of brain pathologies with autonomous externally controllable nanonetworks: a trans-disciplinary approach with bio-nanodevice interfaces  (Gladiator), 2019-2022, 950.000 €    
  • EU FET OPEN, Bridging the gap between Mind, Brain and Body: exosome role and monitoring (MindGAP), 2019-2023, 867.000 €,
  • European Regional Development Fund, PrintoDiSe, 2020-2022, 163.000 €
  • The Gyllenberg Foundation, Impact of Biodynamic Farming on the Strawberries as Depicted Via Nutritional Nanovesicles, (Gyllenberg Strawberry), 2020-2022, 20.000 €
  • Academy of Finland, Development of perfusable vascularized glomeruli model on microfluidic chips (Mobility grant), 2020-2022, 16.000 €
  • Business Finland, Future of Diagnostics-FUDIS (FUDIS), 2020-2022, 311.878 €
  • Academy of Finland Flagship, Gene, Cell and Nano Therapy Competence Cluster for the Treatment of Chronic Diseases (GeneCellNano), 2020-2024, 950.000 €
  • The Finnish Research Impact Foundation, Clinical Validation of Novel Sports and Diabetes Related Analytes Offer New Wearable Diagnostics Solutions (TIA project), 2021-2023, 245.316 €
  • The Finnish Cultural Foundation, Koulutetun ja kaksoissokkotestatun koiran osoittamien SARS-virus PCR tai seropositiivisten näytteiden kliinisbiokemiallinen analyysi (CovidDogs), 2021-2024, 70.000 €
  • Työ- ja elinkeinoministeriö, Liikuntateknologian osaajien ja urheiluseurojen yhteiskehittämisen kansallinen verkosto (LIUKAS), 2021-2024, consortium
  • European Regional Development Fund, CoronaRpTest, 01.06.2020 - 31.10.2021, 280.000 €, Project PI: Florence Naillat