Oulu Functional Neuroimaging

Head: Assoc. Prof. Vesa Kiviniemi

Oulu Functional Neuroimaging is a multi-disciplinary neuroimaging research group at the University of Oulu and Oulu University Hospital. The research is focused on multiscale imaging of brain physiology – both time and space. Our team is collaborating with our leading european primary CNS lymphoma treatment team in our hospital that uses BBB opening to cure the otherwise lethal disease in humans. We are commencing multi-photon imaging of neuromuscular tissue with Eklund’s Biocenter microscopy group on genetic mice models with a special interest in blood brain barrier (BBB) and the glymphatic system. The micro-scale results are compared to the macro-scale human data that is scanned with our novel multimodal scanning environment. We combine ultrafast 10 Hz fMRI technique called magnetic resonance encephalography (MREG) with MRI compatible electroencephalography (DC-EEG, 256-channel EGI), near-infrared spectroscopy (NIRS) and continuous non-invasive blood pressure (NIBP) measurements. Our aim is to monitor treatment related changes in glymphatic mechanisms and BBB both in microscopic scale and in macroscopic human scales with DC-EEG & NIRS used in both scales for data matching.

We collaborate with several local and international research groups which focus on psychiatric and neurologic disorders like schizophrenia, dementia, epilepsy and autism. In 2014 we have initiated CNS lymphoma research focusing on BBBD multimodal monitoring. In 2015 we developed a method to detect short-term activity avalanches in human with ultrafast MREG. In 2016 we revealed two new glymphatic pulsation mechanisms in human brain with the inventor of the glymphatic system prof. Maiken Nedergaard (Kiviniemi et al., JCBFM 2016). OFNI-group is associated with Medical Research Center (MRC), Oulu BioImaging, University of Oulu Graduate School (UniOGS) and are a part of the MIPT (Medical Imaging, Physics and Technology).