Cell-extracellular matrix interactions in stem cell niches and vascular structures

Taina Pihlajaniemi, M.D., Ph.D. and Lauri Eklund, Ph.D.

Project leaders
Prof. Taina Pihlajaniemi, M.D., Ph.D.
Prof. Lauri Eklund, Ph.D.

Oulu Center for Cell–Matrix Research
Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine
University of Oulu

Mailing address
P.O. Box 5000
FIN-90014 University of Oulu, FINLAND

Street address
Aapistie 7, FIN-90220 Oulu, Finland

e-mail: taina.pihlajaniemi (at) oulu.fi, tel. +358-(0)294 485800
e-mail: lauri.eklund (at) oulu.fi, tel. +358-(0)294 486073

Focus area spearhead project web page

About the project

The extracellular matrix (ECM) provides structural support and guidance cues for cells, and is centrally involved in dynamic processes in organogenesis, organ function and diseases. We investigate the structural and regulatory roles of collagens, a key group of ECM proteins in supporting homeostasis and function of cells and tissues. We also study the mechanisms whereby vascular endothelial cells interact with the ECM, and aim for better understanding of physiological angiogenesis and pathological mechanisms responsible for vascular anomalies, focusing on the Tie/angiopoietin signalling system. The project is part of the Finnish Centre of Excellence Programme funded by the Academy of Finland (Centre of Excellence Grant 2012 - 2017, 251314).

Project details

  1. Background and Significance
  2. Recent Progress
  3. Future Goals
  4. Publications 2017-
  5. Research Group Members
  6. National and International Activities

Last updated: 15.10.2018