Elbuken Lab: Microfluidics and Biosensor Research Group

Our research spans the fields of microfluidics, nanofluidics, lab-on-a-chip systems, integrated microsystems, rheology, non-linear fluidics, vascular flow.
red blood cell detection

Research group information

Contact information

Research group leader

  • Professor of biosensors
    Caglar Elbuken

Research group description

We are interested in the study of fluids at micro and nanoscale. Our research studies span the fields of microfluidics, lab-on-a-chip systems and integrated microsystems. Microfluidic technologies enable the use of small scale fluid control and analysis. Compared to their bulky counterparts, microfluidic devices yield faster, higher performance and cost-effective assays. An integral part of our research is the design and fabrication of microfluidic systems.  We work on a very wide range of topics including droplet microfluidics, artificial cells, extracellular vesicle isolation systems, viscoelastic fluids, nonlinear microfluidics and bifurcating fluidic networks. Below a snapshot of our main research themes is given.

Open positions

1 PH.D. STUDENT position is available (post 1) apply until 27 November 2022! 

Our  ERC Consolidator project (BiNET) will start in October 2022.  We will be working on bifurcating network growth and the relationship between short term fluctuations and long term growth. Specifically, we will study the red blood cell distribution in capillary networks and correlate it with the corresponding tissue growth and vascular network adaptation. We will develop in-vivo models using organoid samples, in-vitro models using analogous microfluidic networks and in-silico models by node-based iterative simulation. 

Our Academy of Finland project (#342448) has started as of September 2021. We are working on self-assembly of artificial cell/vesicle like structures for 3D structure formation. We are exploring the relationship between the individual membrane forming unit and the stability of the self-assembled structure. We study particle distribution dynamics in confined microchannels. In this project we take a new approach and study the particle aggregation dynamics in non-confined geometries using synthetic liposomes and polymersomes engineered by microfluidic approaches. If you are interested in working on this project, contact us for potential positions.

Research

Latest news

Our recent article on fabrication of polyrotaxane microcapsules using droplet fluidics is online. In collaboration with Tuncel group (expert on supramolecular chemistry), we synthesized microscale capsules. We are moving towards assembly of larger structures using such capsules.

Our project on "NanoEngineered Self-Assembling Vesicle Production" is funded by Academy of Finland. We aim to synthesize artificial vesicles using microfluidics and control vesicle properties for achieving self-assembly of complex architectures.

Our ERC Consolidator Project on bifurcating networks was accepted. We are starting a 5-year ambitious project focusing on the dynamics of vessel formation and the discrete nature of blood cell transport at capillary level. More information coming soon.

Researchers

  • Caglar Elbuken, Ph.D., Professor
  • Ali Kalantarifard, Ph.D., Post-doctoral researcher
  • Amir Abdorahimzadeh, M.Sc.. Ph.D. student
  • Lauri Rannaste, M.Sc.. Ph.D. student
  • Indraja Sundara Raju, M.Sc.. Ph.D. student
  • Mostafa Bakouei, M.Sc., Ph.D. student
  • Priyadharsini V. Subramaniam, M.Sc. student
  • Niyati Kandikanti, M.Sc. Trainee

Publications

55) P. Beyazkilic, S. Akcimen, C. Elbuken, B. Ortac, S. Cai, E. Bukusoglu, "Contactless pulsed and continuous microdroplet release using photothermal liquid crystals," Advanced Functional Materials, 2022, 2205385, Sept. 2022 [link]. DOI: 10.1002/adfm.202205385

52) B. Derkus, M. Isik, C. C. Eylem, I. Ergin, C. B. Camci, S. Bilgin, C. Elbuken, Y. E. Arslan, M. Akkulak, O. Adali, F. Kiran, B. O. Okesola, E. Nemutlu, and E. Emregul, "Xenogenic neural stem cell-derived extracellular nanovesicles modulate human mesenchymal stem cell fate and reconstruct metabolomic structure," Advanced Biology  2022, 2101317 Aug. 2022 [link]. DOI: 10.1002/adbi.202101317

47) A. Kalantarifard, E. Alizadeh-Haghighi, A. Saateh and C. Elbuken, “Theoretical and experimental limits of monodisperse droplet generation,” Chemical Engineering Science, 229, Jan. 2021, 116093 [link]. DOI: 10.1016/j.ces.2020.116093

46) S. Pekdemir, H.H. Ipekci, M. Serhatlioglu, C. Elbuken and M.S. Onses, “SERS-active linear barcodes by microfluidic-assisted patterning,” Journal of Colloid and Interface Science, 584, 11-18, Feb 2021 [link]. DOI: 10.1016/j.jcis.2020.09.087

45) M. Kaya, I. Bilican, M. Mujtaba, I. Sargin, M.E. Haskoylu, E. T. Oner, K. Zheng, A.R.Boccaccini, D. Cansaran-Duman, M.S. Onses, I. Torun, L. Akyuz, C. Elbuken and M.V. Sørensen, “Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications,” Chemical Engineering Journal, August 2020, 126667 [link]. DOI: 10.1016/j.cej.2020.126667

44) Z. Isiksacan, M. Serhatlioglu and C. Elbuken, “In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow,” Analyst, 145, 5996-6005, July 2020 (cover article) [link]. DOI: 10.1039/D0AN00604A

43) M. Serhatlioglu, Z. Isiksacan and C. Elbuken, “Electro-viscoelastic migration under simultaneously applied microfluidic pressure-driven flow and electric field,” Anal. Chem., 92, 10, 6932–6940, April 2020 [link]. DOI: 10.1021/acs.analchem.9b05620

42) I. Bilican, M. T. Guler, M. Serhatlioglu, T. Kirindi and C. Elbuken, “Focusing-free impedimetric differentiation of red blood cells and leukemia cells: A system optimization,” Sens. Actuators B, 307, 127531, March 2020 [link]. DOI: 10.1016/j.snb.2019.127531

41) A. Saateh, A. Kalantarifard, O.T. Celik, M. Asghari, M. Serhatlioglu and C. Elbuken, “Real-time impedimetric droplet measurement (iDM),” Lab Chip, 19, 3815-3824, November 2019 (cover article) [link]. DOI: 10.1039/C9LC00641A

39) G. Bakan, S. Ayas, M. Serhatlioglu, A. Dana and C. Elbuken, “Reversible decryption of covert nanometer-thick patterns in modular metamaterials,” Optics Letters, 44 (18), 4507-4510, September 2019 [link]. DOI: 10.1364/OL.44.004507

38) Z. Soybaş, S. Şimşek, F.M.B.Erol, U.Ç. Erdoğan, E.N. Şimşek, B. Şahin, M. Marçalı, B.Aydoğdu, Ç. Elbüken and R. Melik, “Real-Time In Vivo Control of Neural Membrane Potential by Electro-Ionic Modulation,” iScience, 17, 347-358, July 2019 [link]. DOI: 10.1016/j.isci.2019.06.038

The complete list of publications.

Patents

1) US 10,048,281 "Cartridge device with segmented fluidics for assaying coagulation in fluid samples," Katrina Petronilla Di Tullio, Jay Kendall Taylor, John Lewis Emerson Campbell, Caglar Elbuken, Shelia Diane Ball, Noam Saul Lightstone

2) US 9,791,407 "A method and an apparatus for the detection of a tagging materia in fluids," Hakan Urey, Havva Yagci Acar, Caglar Elbuken, Basarbatu Can, Osman Vedat Akgun, Fahri Kerem Uygurmen