microfluidics biosensor

Micro/nanofluidics and Biosensor Research Group

Prof. Caglar Elbuken

Research

People

Publications

Patents

News

Teaching

Facility

Join us

 

Our Academy of Finland project (#342448) has started as of September 2021. We will be working on self-assembly of artificial cell/vesicle like structures for 3D structure formation. We will be exploring the relationship between the individual membrane forming unit and the stability of the self-assembled structure. We study particle distribution dynamics in confined microchannels. In this project we take a new approach and study the particle aggregation dynamics in non-confined geometries using synthetic liposomes and polymersomes engineered by microfluidic approaches.
2 new Ph.D. students and 1 post-doctoral researcher will join to our team for this project. 

Research

We are interested in the study of fluids at micro and nanoscale. Our research studies span the fields of microfluidics, lab-on-a-chip systems and integrated microsystems. Microfluidic technologies enable the use of small scale fluid control and analysis. Compared to their bulky counterparts, microfluidic devices yield faster, higher performance and cost-effective assays. An integral part of our research is the design and fabrication of microfluidic systems.  We work on a very wide range of topics including droplet microfluidics, artificial cells, extracellular vesicle isolation systems, viscoelastic fluids, nonlinear microfluidics and bifurcating fluidic networks. Below a snapshot of our main research themes is given. 
 

droplet microfluidics

Droplet microfluidics

Droplet microfluidics, i.e. dispersed two-phase fluidics, are a subclass of microfluidic systems, where the fluid of interest is segmented into individual droplets with the help of an immiscible carrier fluid. These systems enable high throughput, combinatorial studies with extreme precision and automation. We investigate both the fundamentals of droplet formation mechanism and also applications that utilize such droplets such as digital PCR and single cell profiling

extracellular vesicle, exosome

Artificial cells/vesicles, extracellular vesicles

Bottom-up biology and exploration of extracellular vesicles, specifically exosomes, requires precise manipulation of fluids at picoliter volume. We use our expertise in micro/nanofabrication and fluid behavior at nanoscale to make engineered artificial cells and vesicles mimicking the functionality of real-world entities. We also develop tools for high-throughput, high-purity isolation of extracellular vesicles from bodily fluids.  

nonlinear microfluidics

Non-linear microfluidics, fluidic networks, viscoelasticity

Although laminar flow and linear Stokes equation makes life easy at micro and nanoscale, we are also interested in the dark side. The non-linearity in a fluidic system may have many origins; we are specifically working on viscoelastic fluids and the particle carrying fluidic network. We study the transport of particles in bifurcating networks that lays the foundation for material transport in many biological fluidic system.  

People

Caglar Elbuken

Caglar Elbuken, Ph.D.
Group Leader, Professor

Ph.D. Mechanical Engineering
B.Sc. Electrical and Electronics Engineering
ORCID: 0000-0001-8359-6871
office: 308A (Kontinkangas campus)
click for personal profile

Ali Kalantarifard, Ph.D.
Post-doctoral Researcher

Ph.D. Material Science & Nanotechnology
M.Sc. Mechanical Engineering
B.Sc. Mechanical Engineering
ORCID: 0000-0002-7931-6264
office: 301(Kontinkangas campus)
click for personal profile

Lauri Rannaste, M.Sc.
Ph.D. student

M.Sc. Biochemistry and Molecular Medicine
B.Sc. Biochemistry and Molecular Medicine
ORCID: 0000-0001-5047-9716
office: 301(Kontinkangas campus)

 

Amir Abdorahimzadeh, M.Sc.
Ph.D. Student

M.Sc. Mechanical Engineering
B.Sc. Mechanical Engineering
ORCID: 0000-0003-1403-0182
office: 301 (Kontinkangas campus)
click for personal profile

Hanieh Shirvani, B.Sc.
Researcher

B.Sc. Cellular and Molecular Biology
ORCID: -
office: 301 (Kontinkangas campus)
email: hanieh(dot)shirvani(at)oulu(dot)fi

Niyati Kandikanti, M.Sc.
Trainee

M.Sc. Doctor of Pharmacy
B.Sc. Pharmacy
ORCID: 0000-0001-6695-901X
office: 301 (Kontinkangas campus)

 

Priyadharsini V. Subramaniam
M.Sc. Student

B.Sc. Biotechnology
ORCID: 0000-0002-1523-4147
office: 301 (Kontinkangas campus)

 

 

   

Researcher e-mail addresses are typically in the firstname.lastname(at)oulu.fi format.    

Publications

Colloid and Interface Science Cover Analyst cover Lab on a Chip cover Lab on a Chip 2011 cover
46) Pekdemir et al. 2021
44) Isiksacan et al. 2020
41) Saateh et al. 2019
36) Serhatlioglu et al. 2019
22) Isiksacan et al. 2016
14) Cakmak et al. 2013
 10) Glawdel et al. 2011

47) A. Kalantarifard, E. Alizadeh-Haghighi, A. Saateh and C. Elbuken, “Theoretical and experimental limits of monodisperse droplet generation,” Chemical Engineering Science, 229, Jan. 2021, 116093 [link]. DOI: 10.1016/j.ces.2020.116093

46) S. Pekdemir, H.H. Ipekci, M. Serhatlioglu, C. Elbuken and M.S. Onses, “SERS-active linear barcodes by microfluidic-assisted patterning,” Journal of Colloid and Interface Science, 584, 11-18, Feb 2021 [link]. DOI: 10.1016/j.jcis.2020.09.087

45) M. Kaya, I. Bilican, M. Mujtaba, I. Sargin, M.E. Haskoylu, E. T. Oner, K. Zheng, A.R.Boccaccini, D. Cansaran-Duman, M.S. Onses, I. Torun, L. Akyuz, C. Elbuken and M.V. Sørensen, “Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications,” Chemical Engineering Journal, August 2020, 126667 [link]. DOI: 10.1016/j.cej.2020.126667

44) Z. Isiksacan, M. Serhatlioglu and C. Elbuken, “In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow,” Analyst, 145, 5996-6005, July 2020 (cover article) [link]. DOI: 10.1039/D0AN00604A

43) M. Serhatlioglu, Z. Isiksacan and C. Elbuken, “Electro-viscoelastic migration under simultaneously applied microfluidic pressure-driven flow and electric field,” Anal. Chem., 92, 10, 6932–6940, April 2020 [link]. DOI: 10.1021/acs.analchem.9b05620

42) I. Bilican, M. T. Guler, M. Serhatlioglu, T. Kirindi and C. Elbuken, “Focusing-free impedimetric differentiation of red blood cells and leukemia cells: A system optimization,” Sens. Actuators B, 307, 127531, March 2020 [link]. DOI: 10.1016/j.snb.2019.127531

41) A. Saateh, A. Kalantarifard, O.T. Celik, M. Asghari, M. Serhatlioglu and C. Elbuken, “Real-time impedimetric droplet measurement (iDM),” Lab Chip, 19, 3815-3824, November 2019 (cover article) [link]. DOI: 10.1039/C9LC00641A

40) M. Asghari, M. Serhatlioglu, R. Saritas, M. T. Guler and C. Elbuken, “Tape’n roll inertial microfluidics,” Sens. Actuators A, 299, 111630, November 2019 [link]. DOI: 10.1016/j.sna.2019.111630

39) G. Bakan, S. Ayas, M. Serhatlioglu, A. Dana and C. Elbuken, “Reversible decryption of covert nanometer-thick patterns in modular metamaterials,” Optics Letters, 44 (18), 4507-4510, September 2019 [link]. DOI: 10.1364/OL.44.004507

38) Z. Soybaş, S. Şimşek, F.M.B.Erol, U.Ç. Erdoğan, E.N. Şimşek, B. Şahin, M. Marçalı, B.Aydoğdu, Ç. Elbüken and R. Melik, “Real-Time In Vivo Control of Neural Membrane Potential by Electro-Ionic Modulation,” iScience, 17, 347-358, July 2019 [link]. DOI: 10.1016/j.isci.2019.06.038

Click here for a complete list of publications.

Patents

1) US 10,048,281 "Cartridge device with segmented fluidics for assaying coagulation in fluid samples," Katrina Petronilla Di Tullio, Jay Kendall Taylor, John Lewis Emerson Campbell, Caglar Elbuken, Shelia Diane Ball, Noam Saul Lightstone

2) US 9,791,407 "A method and an apparatus for the detection of a tagging material in fluids," Hakan Urey, Havva Yagci Acar, Caglar Elbuken, Basarbatu Can, Osman Vedat Akgun, Fahri Kerem Uygurmen

News

 

Dr. Caglar Elbuken was appointed to the editorial board of MDPI Chemosensors, Electrochemical Devices and Sensors Division.
Our paper on the a novel methodology for rheological characterization of blood was accepted at RSC Analyst as a cover article.
Our project on "NanoEngineered Self-Assembling Vesicle Production" is funded by Academy of Finland. We aim to synthesize artificial vesicles using microfluidics and control vesicle properties for achieving self-assembly of complex architectures. 

Teaching

740387A (5+2 ECTS)
01.09.2021 - 08.10.2021Microfluidics nanofluidics lab-on-a-chip
Life at small scale
ay740160P (2 ECTS)
07.09.2020 - 02.10.2020

 

Facility

Please visit Biocenter Core Facility website to get information about a portion of the infrastructure available. More information is yet to come...
Oulu Kontinkangas Campus Biocenter Oulu Our laboratory

Join us

Our research interests lie in the intersection of engineering and fundamental sciences. We are always looking for enthusiastic researchers to join us. To get more information on available positions, please contact Prof. Caglar Elbuken. You can reach the details of the graduate program from this link.
 
Visiting Address:
Our group is located at University of Oulu, Kontinkangas Campus, Kieppi Building, Biocenter, 3rd floor. For directions click here
 
Mailing Address:
Faculty of Biochemistry and Molecular Medicine
P.O. Box 5400
FI-90014 University of Oulu
Finland
+358 294 485804
 
Shipping Address:
Faculty of Biochemistry and Molecular Medicine
University of Oulu
Aapistie 7B
90220 Oulu
Finland
+358 294 485804

Last updated: 25.9.2021