Structure, Function and Selective Inhibition of ADP-ribosyltransferases

Lari Lehtiö, Ph.D.

Project leader
Docent Lari Lehtiö, Ph.D.

Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine,
University of Oulu

Mailing address
P.O. Box 3000, FIN-90014 University of Oulu, Finland

Street address
University of Oulu, Aapistie 7A, FIN-90220 Oulu, Finland

Tel. +358-(0)294 481169,
e-mail: lari.lehtio (at)

About the project

ADP-ribosylation is a covalent post-translational protein modification involved in many cellular signalling events. We study the structures and mechanisms of the enzymes involved and aim to develop potent and selective inhibitors to be used as drug leads and as chemical tools to study the enzymes. We develop assays suitable for high-throughput screening of inhibitors and use structural information for more rational design. Protein X-ray crystallography is our main tool used to understand structure-activity relationships of compounds. We also use X-ray crystallography, small angle X-ray scattering and other biophysical techniques to study the structure and function of these multidomain proteins.

Project details

  1. Background and Significance
  2. Recent Progress
  3. Future Goals
  4. Publications 2017-
  5. Research Group Members
  6. National and International Activities

Last updated: 15.10.2018