Regulation of Epithelial Cell Functions by Integrins and the Extracellular Matrix

Aki Manninen, Ph.D.

Project leader
Aki Manninen, Adjunct Professor of Cell Biology, Ph.D.

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu

Mailing address
P.O.Box 5000, FIN-90014 University of Oulu, Finland

Street address
Aapistie 5A, FIN-90220 Oulu, Finland

Tel. +358-(0)294 486081
e-mail: aki.manninen (at)

About the project

Polarized epithelial cells are crucial building blocks of most of our organs. Importantly, deregulated epithelial cell functions contribute to common and severe diseases such as fibrosis and cancer. Our group studies the mechanisms how the extracellular matrix (ECM) regulates epithelial cell polarization and morphogenesis. We are particularly interested in the role of ECM-binding integrin receptors that form large multiprotein complexes at cell-ECM interface and thereby orchestrating bidirectional communication between cells and their microenvironment. The project is part of the Finnish Centre of Excellence Programme funded by the Academy of Finland (Centre of Excellence Grant 2012 - 2017, 251314).

Project details

  1. Background and Significance
  2. Recent Progress and Future Goals
  3. Selected Publications
  4. Doctoral Theses
  5. Research Group Members

Last updated: 15.10.2018