Seventy-two new genetic variants that contribute to the risk of developing breast cancer have been identified by an extensive, international team of researchers. The findings were reported in the journals Nature and Nature Genetics. Genetic studies pave way for understanding the pathogenesis of breast cancer.
The findings are the result of work by the OncoArray Consortium, a huge endeavour involving 550 researchers from around 300 different institutions in six continents. In total, they analysed genetic data from 275,000 women, of whom 146,000 had been diagnosed with breast cancer. The Finnish collaborators in the OncoArray Consortium are the University of Eastern Finland, the University of Helsinki, and the University of Oulu. From Biocenter Oulu, Professor Robert Winqvist and Academy Researcher Katri Pylkäs contributed to these studies.
More information: http://www.oulu.fi/university/node/48919
Find the articles here:
- Michailidou, K et al. Association analysis identifies 65 new breast cancer risk loci. Nature; 23 Oct 2017; DOI: 10.1038/nature24284
- Milne, RL et al. Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nature Genetics; 23 Oct 2017; DOI: 10.1038/ng.3785
Last updated: 27.10.2017