Spearhead projects - Life-long health

Projects 2020-2023

Mika Ala-Korpela and Johannes Kettunen: Extensive molecular profiling of systemic metabolism to understand and prevent cardiometabolic diseases

Lauri Eklund and Vesa Kiviniemi: Neuro-ocular clearance pathways - Mechanisms and clinical applications

Jukka Hakkola and Janne Hukkanen: Environmental xenosensor PXR as a disease mechanism and therapeutic target in metabolic diseases

Simo Hosio and Denzil Ferreira: ICON: Interventions and Contextual Understanding for Low Back Pain Research

Jouni J. K. Jaakkola and Maritta S. Jaakkola: Molecular and environmental basis for asthma in a changing climate

Peppi Karppinen: Cellular oxygen sensors and other 2-oxoglutarate-dependent enzymes as novel treatment targets for diseases

Risto Kerkelä and Juhani Junttila: Genetic causes and molecular mechanisms of myocardial fibrosis

Thomas Kietzmann: Cellular Compartments and New Molecules Interacting in Hypoxia-Signaling and Associated Diseases

Petri Kursula: Structural biology of the formation and disease of the multilayered myelin membrane

Lari Lehtiö: Structure, Function and Inhibition of Human ADP-ribosyltransferases

Johanna Myllyharju: Key enzyme regulators of the hypoxia response and collagen synthesis as therapeutic targets

Katri Pylkäs and Robert Winqvist: Inherited breast cancer susceptibility: novel factors, cellular mechanisms and disease modelling

Justus Reunanen: Secreted vesicles of the human intestinal microbiota in health and disease

Gonghong Wei and Aki Manninen: Transcription factor cistromes decode prostate cancer risk loci

Projects 2016-2019

Mika Ala-Korpela and Johannes Kettunen: Population-based stratification of individual cardiovascular risk — a multi-omics approach

Inari Kursula: Molecular mechanisms of parasite motility

Johanna Myllyharju and Peppi Karppinen: Hypoxia Response Pathway as a Target for Novel Therapeutics

Taina Pihlajaniemi and Lauri Eklund: Cell-extracellular matrix interactions in stem cell niches and vascular structures

Justus Reunanen: Innovative approaches to explore host-microbiota interactions and to discover novel antibiotics – functional metamining of the human intestinal microbiome

Lloyd Ruddock: Mechanisms and applications of disulfide bond formation

Markku Savolainen, Karl-Heinz Herzig and Marjo-Riitta Järvelin: Molecular Determinants of Metabolic Syndrome (Metsyn)

Outi Savolainen, Mikko Sillanpää and Tanja Pyhäjärvi: Genomic and Statistical Analysis of Genotype-Phenotype Relationships

Johanna Uusimaa and Reetta Hinttala: Dysfunction of cellular metabolic and signalling pathways behind severe neurological and multiorgan diseases in children

Seppo Vainio: Mechanisms of Organogenesis

Gonghong Wei: Functional Genomics and Systems Genetics in Cancer

Rikkert K. Wierenga: Structural Enzymology: A Quantitative Approach

Robert Winqvist: Factors and Mechanisms in Hereditary Breast Cancer Predisposition