Spearhead projects - Lifelong health 2020 - 2023 Project Cellular Compartments and New Molecules Interacting in Hypoxia-Signaling and Associated Diseases - Thomas Kietzmann 2020 - 2023 Project Cellular oxygen sensors and other 2-oxoglutarate-dependent enzymes as novel treatment targets for diseases - Peppi Karppinen 2020 - 2023 Project Environmental xenosensor PXR as a disease mechanism and therapeutic target in metabolic diseases - Jukka Hakkola and Janne Hukkanen 2020 - 2023 Project Extensive molecular profiling of systemic metabolism to understand and prevent cardiometabolic diseases - Mika Ala-Korpela and Johannes Kettunen 2020 - 2023 Project Genetic causes and molecular mechanisms of myocardial fibrosis - Risto Kerkelä and Juhani Junttila 2020 - 2023 Project ICON: Interventions and Contextual Understanding for Low Back Pain Research - Simo Hosio and Denzil Ferreira 2020 - 2023 Project Inherited breast cancer susceptibility: novel factors, cellular mechanisms and disease modelling - Katri Pylkäs and Robert Winqvist 2020 - 2023 Project Integrin Signaling and Transcriptional Networks in Cancer - Aki Manninen 2020 - 2023 Project Key enzyme regulators of the hypoxia response and collagen synthesis as therapeutic targets - Johanna Myllyharju 2020 - 2023 Project Molecular and environmental basis for asthma in a changing climate - Jouni J. K. Jaakkola and Maritta S. Jaakkola 2020 - 2023 Project Neuro-ocular clearance pathways - Mechanisms and clinical applications - Lauri Eklund and Vesa Kiviniemi 2020 - 2023 Project Secreted vesicles of the human intestinal microbiota in health and disease - Justus Reunanen 2020 - 2023 Project Structural biology of the formation and disease of the multilayered myelin membrane - Petri Kursula 2020 - 2023 Project Structure, Function and Inhibition of Human ADP-ribosyltransferases - Lari Lehtiö