NFBC's Genetic Projects

Person(s) in charge

Institution (s)

Title

Cohort

Status

Freathy, Jarvelin, McCarthy, Peltonen, et al.

Imperial College London, UK, U Oulu, U Oxford etc

GWA on gestational age and birth weight adjusted for gestational age. Meta-analysis of several data sets including NFBC1966.

1966

Analyses underway

Freimer, Veijola J, Paunio,  Mannila, Peltonen, Jarvelin

UCLA, US, U Oulu, U Helsinki, Imperial College London

GWA, personality features and psychiatric disorders (“phenome project”)

1966

Analyses underway

Froguel, Cauchi, Jarvelin, Elliott et al.

Pasteur Institute, Lille, France

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations

1986

Published, further work underway

Froguel, Cauchi, Jarvelin, McCarthy, Elliott et al.

Pasteur Institute, Lille, France

A multi-stage genome-wide association study on  insulin resistance, hyperinsulinemia and type 2 diabetes.

1986

Analyses underway

Jarvelin, Sovio,  et al

 

 

 

 

Jarvelin, Sovio, Pouta, Hirschorn, Peltonen, McCarthy et al

 

Timpson, Sovio, McCarthy, Jarvelin et al

Imperial College London, UK,  U Oulu, U Oxford, U Helsinki,

Sanger Institute

Genetic association analysis from a life-course perspective (in particular growth) in the Northern Finland Birth Cohort 1966.

 

 

Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the Northern Finland Birth Cohort1966

 

FTO gene and longitudinal weight gain (obesity) – several datasets included (NFBCs,  ALSPAC, RAINE, Helsinki cohort)

1966

 

 

 

 

1966, 1986

 

 

 

 

1966, 1986

PhD project

 

 

 

 

Part of this published, further work underway

 

 

Analyses underway

Widen, Ripatti, Sovio, Peltonen, Jarvelin et al

Molecular Medicine Technology Center, FIMM, Finland

The Genetic Regulation of Pubertal Timing: Identification of Genetic Variants Influencing Puberty Timing and Longitudinal Growth During Adolescence.

 

Underway

Jarvelin, Kaakinen, Laara, Molitor, De Stavola et al

U Oulu, Biocenter Oulu, Imperial College London etc

Structural equation and hierarchical models in analyzing genetic and lifecourse data.  Methodological comparisons.

1966, 1986

PhD project

Bouatia-Naji,  Froguel, Jarvelin et al

Pasteur Institute, Lille, France

Fine mapping studies  (related to T2D/glucose metabolism)

1966 and 1986

Analyses underway

Jarvelin, Pillas, Coin, Sovio  et al

Imperial College London, UK, U Oulu

Genome-wide association studies related to organogenesis and developmental milestones in the Northern Finland Birth Cohort 1966.  Collaborative project with ALSPAC, Generation R, Raine (as appropriate)

1966

PhD project,

Analyses underway

McCarthy, Procopenco et al

U Oxford etc

GWA and metabolic outcomes (T2D and Obesity related),

Analyses for MAGIC/GIANT consortiums (e.g. fasting glucose homeostasis

1966

Published/analyses underway

Davey-Smith,  Jarvelin M-R,  Sovio, Kettunen, McCarthy, Peltonen

Bristol University, Imperial College London, UK, U Oulu

Lactase SNP, milk drinking and metabolic outcomes in the NFBC1966.

1966

First part under review, further work ongoing

Elliott, Jarvelin et al

Imperial College London, U Oulu etc

GWA and BP,  Analyses for GlobalBP consortium

1966, 1986

In press, further analyses underway

Elliott, Jarvelin et al

Imperial College London, U Oulu etc

GWA and CRP/ CVD (Mendelian randomization approach)

1966

Review process, further work underway

Cookson, Jarvelin, Hirschorn, Lyon, Elliott, Strachan, Peltonen et al

Imperial College London, Broad Institute, U Oulu etc

GWA and asthma (as a part of GABRIEL)

(+ atopy studies)

1966

Analyses underway

Jarvelin, Elliott, Freimer, Schuman, Peltonen et al

Imperial College London, Kings College, Broad Institute, Sanger, U Oulu etc

GWA and alcohol drinking (as a part of Engage programme)

1966

Analyses underway

OTHER CONSORTIA,

WORK ON ITS WAY (leading unit)

E=part of engage

Many

Liver function – except bilirubin analyses (Imperial) E

Bilirubin analyses (Kings) E

Kidney function (Imperial) E

Vitamin D Analyses (Kings) (E)

Smoking analyses (Decode)  E

Inflammaroty markers (Stampeed)

Haemoglobin and other haematological measures

Musculoskeletal disorders (Imperial)

1966

Analyses underway

Ripatti, Peltonen et al.

Helsinki, Sanger

CNV analysis, rare large CNVs and correlation with psychiatric phenotypes, population genetics of CNVs, common CNVs and correlation with metabolic phenotypes

1966

Manuscript draft, analyses underway

 

 

 

 

 

 

Last updated: 1.7.2013