RESEARCH PROJECTS IN PEDIATRIC NEUROLOGY
1. Febrile seizures
Different aspects of febrile seizures have been studied since 1985. The ongoing research is concerned with the causes of febrile seizures. The role Ca-ion channels and interleukins is now under evaluation as causative factors of febrile seizures.
Febrile seizures study group: Heikki Rantala, Kirsi Mikkonen, Maria Harvio, Ulla Jounio, Matti Uhari.
2. Dysfunction of cell energy metabolism and cell signaling pathways in children and mitochondria-targeted drug-toxicity
Since 1990 we have studied the clinical features, genetic etiologies and pathomechanisms of mitochondrial diseases in children. During the recent years, in collaboration with the University of Oxford (Oxford, UK), the McGill University (Montreal, Canada) and the Mitochondrial Clinical & Research Network (MCRN) of 8 European Centers, our research has been focused on dysfunction of cell energy metabolism and cell signalling pathways associated with childhood encephalomyopathies and cerebrohepatic manifestations as well as on studies related to mitochondria-targeted drug toxicity.
Study group: Johanna Uusimaa, Heikki Rantala, Reetta Hinttala, Johanna Annunen-Rasila, Heidi Soini, Tuomas Komulainen, Johanna Hynynen, Maija Bolszak, Paula Widgren, Salla Pakanen, Naemeh Nayebzadeh, and Milla-Riikka Hautakangas from the Department of Pediatrics and many national and international collaborators.
3. Genetic epilepsies in Northern Finland (POGE study)
The POGE study is focused on the genetic etiologies and pathomechanisms of inherited epilepsies and genetic risk factors associated with the side effects of antiepileptic drugs. Currently, the study population consists of more than 1000 children and adult patients with epiilepsy.
Study group: Johanna Uusimaa, Heikki Rantala, Reetta Hinttala, and Jonna Komulainen-Ebrahim from the Department of Pediatrics, Hanna Ansakorpi, Kari Majamaa, Jouko Isojärvi and Eemeli Saastamoinen from the Department of Neurology, and many national collaborators.
4. Brain tumors
The treatment of childhood brain tumors has developed during the last four decades so that 70-74 % of children will become 5-year survivors of their primary CNS malignancy. This improved outcome has resulted in a new and growing population of childhood cancer survivors. The ongoing study is evaluating the long term outcome of childhood brain tumor survivors treated in all university hospitals in Finland.
Study group: Tiina Remes, Heikki Rantala, Arja-Harila-Saari, Marja Ojaniemi from the Department of Pediatrics in Oulu with collaborators of all other university hospitals in Finland.
Viimeksi päivitetty: 28.4.2014