Longitudinal course and outcomes in psychoses, and beneficial and harmful effects of antipsychotics in psychoses and off-label use - the Northern Finland Birth Cohorts 1986 and 1966

Group leader
Docent Erika Jääskeläinen

Background and significance

Mental disorders and psychoses are important public health problems. Antipsychotics  (APs) are common treatments in these disorders. The Northern Finland Birth Cohort 1966 (NFBC 1966) psychosis subproject has major contribution in studying schizophrenia. Now the aim is to analyse course of illness and prognosis in also in non-schizophrenia psychoses (and schizophrenia) in both NFBC 1966 and also in NFBC 1986. In addition, we aim to expand the AP arm into detailed study of benefits and harmful effects of APs regardless of diagnostic classes.

Though recovery is possible, the prognosis of schizophrenia is still relatively poor. There is very little information on prognosis and course of illness in non-schizophrenic psychoses. The effectiveness and adverse effects of APs in psychoses after the first two years, and their effectiveness and adverse effects in off-label use are poorly understood. NFBC 1966 and 1986 offers a unique possibility to study AP effects in real-world setting by prospectively collected data since mid-pregnancy and large national registers.

Future goals

In the future, the aims are:

To analyse longitudinal course of illness in non-schizophrenic psychoses (psychotic bipolar disorder, psychotic depression, brief psychosis, psychosis NOS), in comparison to schizophrenia and for example depression.

To compare the course of illness in psychoses in the NFBC 1966 and 1986.

To find predictors of good and poor course of illness in psychoses.

To analyse beneficial and harmful effects of antipsychotic medications in psychoses and in off-label use.

To analyse what predicts antipsychotic effects.

Research funding 

  • Sigrid Jusélius Foundation
  • Academy of Finland
  • the Brain and Behavior Research Foundation
  • Pohjois-Suomen terveydenhuollon tukisäätiö
  • Duodecim Oulu
  • VTR-funding

Research group members

Post-doctoral researchers:

  • Marianne Haapea, PhD
  • Matti Penttilä, MD, PhD
  • Irina Rannikko, Psychologist, PhD

PhD students:

  • Anja Husa, MD
  • Hanna Korpela, M.Soc.Sc, BM
  • Annika Seppälä, BSc, BM
  • Johanna Immonen, MSc (Econ.), BM

Other personnel:

  • Teija Juola, MA

Most important collaborators

  1. Jouko Miettunen, Professor, University of Oulu, Finland
  2. Jussi Seppälä, MD, PhD, University of Oulu, Finland
  3. Graham Murray, MD, PhD, University of Cambridge, UK
  4. Anthony Ahmed, PhD, Assistant Professor, Weill Cornell Medical College, US
  5. Nina Rautio, PhD, University of Oulu, Finland
  6. Matti Isohanni, Professor (emeritus), University of Oulu, Finland
  7. Hannu Koponen, Professor, Dept. Psychiatry, University of Helsinki
  8. Peter Jones, Professor, University of Cambridge, UK
  9. Jennifer Barnett, PhD, University of Cambridge, UK
  10. John McGrath, Professor, University of Queensland, Australia

M-RESIST Group (www.mresist.eu)

Last updated: 31.10.2018